DegronMD

Uniprot ID: Q12918

Source protein: Killer cell lectin-like receptor subfamily B member 1

Source gene: KLRB1

Class: DEG_SCF_TRCP1_1

Location: 15:21

E3 ligase: BTRC

DEGRON score: 0.7797

ASA_SCORE: 95

COIL: 0.9753

CONS_SCORE: 0.2456

DSS_SCORE: 0.6525

HELIX: 0.0124

FCONS_SCORE: 0.6995

RIG_SCORE: 0.5481

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I6V	TCGA-86-8074	LUAD	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.0833
p.I6V	DO25330	LUAD	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.0833
p.R28Q	TCGA-A5-A0G2	UCEC	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.1389
p.R28Q	TCGA-AX-A05S	UCEC	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.1389
p.R28Q	DO43218	UCEC	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.1389
p.R28Q	DO41235	UCEC	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.1389
p.R28W	TCGA-AG-A002	READ	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.1389
p.R28W	EFO-27	ovary	COSMIC	DSGPESS	DEG_SCF_TRCP1_1	0.1389
p.S20C	TCGA-AG-A02N	READ	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.643
p.S20C	DO37146	READ	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.643
p.E19K	TCGA-EE-A2MI	SKCM	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.591
p.E19K	TCGA-FD-A5BS	BLCA	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.591
p.E19K	DO44047	BLCA	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.591
p.E19K	DO37531	SKCM	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.591
p.E9D	TCGA-OR-A5J1	ACC	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.1667
p.P23T	TCGA-QH-A6CV	LGG	TCGA	DSGPESS	DEG_SCF_TRCP1_1	0.2778
p.P23T	DO50169	LGG	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.2778
p.A5V	DO223076	ESCA	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.0556
p.T14K	DO229045	LICA	ICGC	DSGPESS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12918	Killer cell lectin-like receptor subfamily B member 1	DEG_SCF_TRCP1_1	15:21	DSGPESS	BTRC	0.7797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons