DegronMD - Q9Y2L6(FRMD4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R691W	TCGA-32-2616	GBM	TCGA	PESSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1667
p.R691W	DO13462	GBM	ICGC	PESSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1667
p.R840L	TCGA-55-8090	LUAD	TCGA	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.25
p.R840L	DO23554	LUAD	ICGC	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.25
p.R656W	TCGA-AJ-A3BH	UCEC	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.1389
p.R656W	DO41638	UCEC	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.1389
p.S684L	TCGA-AP-A1DP	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.7667
p.S684L	DO42336	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.7667
p.P800S	TCGA-B1-A654	KIRP	TCGA	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.5641
p.P800S	DO49739	KIRP	ICGC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.5641
p.Y833C	TCGA-B6-A0IH	BRCA	TCGA	NDTEGQYSVNP	CBL_PTK	827:837	Mutation altering degron motif	0.7087
p.Y833C	DO2749	BRCA	ICGC	NDTEGQYSVNP	CBL_PTK	827:837	Mutation altering degron motif	0.7087
p.S820R	TCGA-BF-AAP0	SKCM	TCGA	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1389
p.S820R	DO219462	SKCM	ICGC	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1389
p.L669V	TCGA-BR-A4CQ	STAD	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation altering degron motif	0.5654
p.L669V	DO47861	STAD	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation altering degron motif	0.5654
p.R656Q	TCGA-CD-A4MG	STAD	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.1389
p.R656Q	TCGA-WS-AB45	COAD	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.1389
p.R656Q	DO51734	COAD	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.1389
p.R656Q	DO48009	STAD	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.1389
p.Y809C	TCGA-FI-A2D0	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1667
p.Y809C	DO43891	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1667
p.S842L	TCGA-JW-A5VL	CESC	TCGA	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1944
p.S842L	DO49976	CESC	ICGC	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1944
p.H844N	TCGA-VS-A9U6	CESC	TCGA	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1389
p.H844N	DO219728	CESC	ICGC	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1389
p.G659E	TCGA-W3-A828	SKCM	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.2222
p.G659E	DO51273	SKCM	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.2222
p.A807T	TCGA-WS-AB45	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2222
p.A807T	DO51734	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2222
p.A813T	DO225186	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0556
p.A813T	DO227932	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0556
p.S803T	DO224973	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.6005
p.S803T	DO52555	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.6005
p.S677I	DO233767	GACA	ICGC	AYSSS	DEG_SPOP_SBC_1	673:677	Mutation altering degron motif	0.7341
p.H687N	DO229019	LICA	ICGC	AYSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.0556
p.H687N	DO229019	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.2778
p.P664T	DO229032	LICA	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation altering degron motif	0.5919
p.P667T	DO229036	LICA	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation altering degron motif	0.7031
p.Q658K	DO229038	LICA	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.1944
p.R691Q	DO228263	MALY	ICGC	PESSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1667
p.G808V	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.G808V	ACH-000563	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.G808V	EBC-1	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.S685C	SIDM00670	Pancreatic Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.7541
p.S685C	SIDM00123	Kidney Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.7541
p.A843S	SIDM00783	Colorectal Carcinoma	GDSC	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1667
p.A843S	ACH-000971	Colon/Colorectal Cancer	CCLE	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1667
p.A843S	HCT-116	large intestine	COSMIC	NDTEGQYSVNP	CBL_PTK	827:837	Mutation rewiring degron network	0.1667
p.P800R	ACH-001459	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.6401
p.D679Y	SK-N-DZ	autonomic ganglia	COSMIC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation rewiring degron network	0.0833
p.D679Y	SK-N-DZ	autonomic ganglia	COSMIC	AYSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.2778
p.D679Y	SK-N-DZ	autonomic ganglia	COSMIC	PESSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.2778
p.E668K	SR	haematopoietic and lymphoid tissue	COSMIC	MPTTPVLT	DEG_SCF_FBW7_1	663:670	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRMD4B

UniProt ID: Q9Y2L6

Entrez ID: 23150

Protein name: FERM domain-containing protein 4B (GRP1-binding protein GRSP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRMD4B in