DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NDTEGQYSVNP
Uniprot ID:
Q9Y2L6
Source protein:
FERM domain-containing protein 4B
Source gene:
FRMD4B
Class:
CBL_PTK
Location:
827:837
E3 ligase:
CBL
DEGRON score:
0.9933
ASA_SCORE:
81.8545
COIL:
0.8351
CONS_SCORE:
0.337
DSS_SCORE:
0.3958
HELIX:
0.0618
FCONS_SCORE:
1.1459
RIG_SCORE:
0.7688
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R840L
TCGA-55-8090
LUAD
TCGA
NDTEGQYSVNP
CBL_PTK
0.25
p.R840L
DO23554
LUAD
ICGC
NDTEGQYSVNP
CBL_PTK
0.25
p.Y833C
TCGA-B6-A0IH
BRCA
TCGA
NDTEGQYSVNP
CBL_PTK
0.7087
p.Y833C
DO2749
BRCA
ICGC
NDTEGQYSVNP
CBL_PTK
0.7087
p.S820R
TCGA-BF-AAP0
SKCM
TCGA
NDTEGQYSVNP
CBL_PTK
0.1389
p.S820R
DO219462
SKCM
ICGC
NDTEGQYSVNP
CBL_PTK
0.1389
p.S842L
TCGA-JW-A5VL
CESC
TCGA
NDTEGQYSVNP
CBL_PTK
0.1944
p.S842L
DO49976
CESC
ICGC
NDTEGQYSVNP
CBL_PTK
0.1944
p.H844N
TCGA-VS-A9U6
CESC
TCGA
NDTEGQYSVNP
CBL_PTK
0.1389
p.H844N
DO219728
CESC
ICGC
NDTEGQYSVNP
CBL_PTK
0.1389
p.A843S
SIDM00783
Colorectal Carcinoma
GDSC
NDTEGQYSVNP
CBL_PTK
0.1667
p.A843S
ACH-000971
Colon/Colorectal Cancer
CCLE
NDTEGQYSVNP
CBL_PTK
0.1667
p.A843S
HCT-116
large_intestine
COSMIC
NDTEGQYSVNP
CBL_PTK
0.1667
Drug responses associated with FRMD4B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NDTEGQYSVNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y2L6
FERM domain-containing protein 4B
CBL_PTK
827:837
NDTEGQYSVNP
CBL
0.9933
More...
