DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
AYSSS
Uniprot ID:
Q9Y2L6
Source protein:
FERM domain-containing protein 4B
Source gene:
FRMD4B
Class:
DEG_SPOP_SBC_1
Location:
673:677
E3 ligase:
SPOP
DEGRON score:
0.999
ASA_SCORE:
68.16
COIL:
0.768
CONS_SCORE:
0.3896
DSS_SCORE:
0.6838
HELIX:
0.1922
FCONS_SCORE:
1.0849
RIG_SCORE:
0.6224
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S677I
DO233767
GACA
ICGC
AYSSS
DEG_SPOP_SBC_1
0.7341
p.H687N
DO229019
LICA
ICGC
AYSSS
DEG_SPOP_SBC_1
0.0556
p.D679Y
SK-N-DZ
autonomic_ganglia
COSMIC
AYSSS
DEG_SPOP_SBC_1
0.2778
Drug responses associated with FRMD4B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AYSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15047
Histone-lysine N-methyltransferase SETD1A
DEG_SPOP_SBC_1
286:290
AYSSS
SPOP
0.992
More...
P17661
Desmin
DEG_SPOP_SBC_1
4:8
AYSSS
SPOP
0.9409
More...
Q00613
Heat shock factor protein 1
DEG_SPOP_SBC_1
246:250
AYSSS
SPOP
0.885
More...
Q14191
Werner syndrome ATP-dependent helicase
DEG_SPOP_SBC_1
1137:1141
AYSSS
SPOP
0.5977
More...
Q7Z6R9
Transcription factor AP-2-delta
DEG_SPOP_SBC_1
39:43
AYSSS
SPOP
0.9904
More...
Q7Z739
YTH domain-containing family protein 3
DEG_SPOP_SBC_1
150:154
AYSSS
SPOP
0.9975
More...
Q9Y2L6
FERM domain-containing protein 4B
DEG_SPOP_SBC_1
673:677
AYSSS
SPOP
0.999
More...
A8MTZ7
Uncharacterized protein C12orf71
DEG_SPOP_SBC_1
2:6
AYSSS
SPOP
0.8548
More...