DegronMD - Q7Z6R9(TFAP2D)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H143N	TCGA-34-8455	LUSC	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6312
p.H143N	DO50095	LUSC	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6312
p.R142S	TCGA-39-5034	LUSC	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7427
p.R142S	DO26854	LUSC	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7427
p.M156I	TCGA-49-AAR4	LUAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.M156I	DO218920	LUAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.M156I	SIDM00507	Other Solid Cancers	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.M156I	ACH-001490	Lung Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.M156I	COR-L321	NS	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.T50A	TCGA-85-A512	LUSC	TCGA	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389
p.T50A	TCGA-DX-AATS	SARC	TCGA	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389
p.T50A	DO45425	LUSC	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389
p.T50A	DO220071	SARC	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389
p.G155E	TCGA-86-8073	LUAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.G155E	TCGA-D3-A8GM	SKCM	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.G155E	DO23624	LUAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.G155E	DO50288	SKCM	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.G52A	TCGA-A5-A0G1	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.G52A	DO42472	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.R141H	TCGA-AA-3821	COAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7133
p.R141H	TCGA-D5-6930	COAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7133
p.R141H	DO9314	COAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7133
p.R141H	DO10550	COAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7133
p.R141H	DO233918	GACA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7133
p.P45T	TCGA-AP-A056	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2778
p.P45T	DO43971	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2778
p.L46I	TCGA-AX-A2HC	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.25
p.L46I	DO41572	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.25
p.A39T	TCGA-AZ-4615	COAD	TCGA	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.7139
p.A39T	DO7977	COAD	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.7139
p.G135A	TCGA-CD-A4MI	STAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.G135A	DO47717	STAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.L145V	TCGA-DX-A1KX	SARC	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6765
p.L145V	DO219946	SARC	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6765
p.C29Y	TCGA-NC-A5HN	LUSC	TCGA	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.C29Y	DO52025	LUSC	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.P45S	TCGA-VQ-A8PO	STAD	TCGA	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2778
p.P45S	DO51773	STAD	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2778
p.S149G	TCGA-VQ-A924	STAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.5882
p.S149G	DO51795	STAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.5882
p.M156K	TCGA-WB-A81T	PCPG	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.D138N	DO8264	COAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.25
p.R141C	DO230312	COCA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.719
p.R141C	SIDM02015	Colorectal Carcinoma	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.719
p.E133K	DO234250	ESAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.R132Q	DO233885	GACA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.S49Y	DO228245	LICA	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.G135C	DO229022	LICA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.R142L	DO229041	LICA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8428
p.S44C	DO23218	LINC	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.H150L	DO231120	LUSC	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.3056
p.T53I	DO228349	MALY	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.T53I	SIDM00656	Burkitt's Lymphoma	GDSC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.T53I	SIDM00641	Burkitt's Lymphoma	GDSC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.T53I	ACH-000944	Lymphoma	CCLE	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.T53I	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.D159N	DO222710	MELA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0556
p.T51A	DO51477	PACA	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1111
p.R141S	DO228174	PBCA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6316
p.V33L	DO51954	PRAD	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.S44F	DO229456	SKCA	ICGC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.H143Q	SIDM00652	Small Cell Lung Carcinoma	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.647
p.H143Q	ACH-000780	Lung Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.647
p.H143Q	NCI-H1105	lung	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.647
p.R142C	SIDM00919	Ovarian Carcinoma	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8301
p.R142C	ACH-000713	Ovarian Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8301
p.R142C	Caov-3	ovary	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8301
p.G155R	SIDM00853	Other Sarcomas	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.G155R	ACH-000835	Sarcoma	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.G155R	GCT	soft tissue	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1667
p.Y48C	SIDM00217	Colorectal Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.Y48C	ACH-000999	Colon/Colorectal Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.Y48C	SNU-1040	large intestine	COSMIC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.G151C	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2778
p.G151C	ACH-000855	Esophageal Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2778
p.G151C	KYSE-150	oesophagus	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2778
p.V38A	SIDM01753	Gastric Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.V38A	ACH-000239	Gastric Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.M156R	ACH-000122	Leukemia	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.H157N	ACH-001692	Head and Neck Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFAP2D

UniProt ID: Q7Z6R9

Entrez ID: 83741

Protein name: Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TFAP2D in