DegronMD

Uniprot ID: Q7Z6R9

Source protein: Transcription factor AP-2-delta

Source gene: TFAP2D

Class: DEG_APCC_DBOX_1

Location: 141:149

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7478

ASA_SCORE: 71.9778

COIL: 0.6896

CONS_SCORE: 0.4525

DSS_SCORE: 0.2864

HELIX: 0.2154

FCONS_SCORE: 1.0925

RIG_SCORE: 0.7296

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H143N	TCGA-34-8455	LUSC	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.6312
p.H143N	DO50095	LUSC	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.6312
p.R142S	TCGA-39-5034	LUSC	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.7427
p.R142S	DO26854	LUSC	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.7427
p.M156I	TCGA-49-AAR4	LUAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.1389
p.M156I	DO218920	LUAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1389
p.M156I	SIDM00507	Other Solid Cancers	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1389
p.M156I	ACH-001490	Lung Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	0.1389
p.M156I	COR-L321	NS	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1389
p.G155E	TCGA-86-8073	LUAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.G155E	TCGA-D3-A8GM	SKCM	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.G155E	DO23624	LUAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.G155E	DO50288	SKCM	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.R141H	TCGA-AA-3821	COAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.7133
p.R141H	TCGA-D5-6930	COAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.7133
p.R141H	DO9314	COAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.7133
p.R141H	DO10550	COAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.7133
p.R141H	DO233918	GACA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.7133
p.G135A	TCGA-CD-A4MI	STAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.G135A	DO47717	STAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.L145V	TCGA-DX-A1KX	SARC	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.6765
p.L145V	DO219946	SARC	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.6765
p.S149G	TCGA-VQ-A924	STAD	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.5882
p.S149G	DO51795	STAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.5882
p.M156K	TCGA-WB-A81T	PCPG	TCGA	RRHDLSLMS	DEG_APCC_DBOX_1	0.1389
p.D138N	DO8264	COAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.25
p.R141C	DO230312	COCA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.719
p.R141C	SIDM02015	Colorectal Carcinoma	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	0.719
p.E133K	DO234250	ESAD	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1111
p.R132Q	DO233885	GACA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.0833
p.G135C	DO229022	LICA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.R142L	DO229041	LICA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.8428
p.H150L	DO231120	LUSC	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.3056
p.D159N	DO222710	MELA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.0556
p.R141S	DO228174	PBCA	ICGC	RRHDLSLMS	DEG_APCC_DBOX_1	0.6316
p.H143Q	SIDM00652	Small Cell Lung Carcinoma	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	0.647
p.H143Q	ACH-000780	Lung Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	0.647
p.H143Q	NCI-H1105	lung	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	0.647
p.R142C	SIDM00919	Ovarian Carcinoma	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	0.8301
p.R142C	ACH-000713	Ovarian Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	0.8301
p.R142C	Caov-3	ovary	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	0.8301
p.G155R	SIDM00853	Other Sarcomas	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.G155R	ACH-000835	Sarcoma	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.G155R	GCT	soft_tissue	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	0.1667
p.G151C	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	RRHDLSLMS	DEG_APCC_DBOX_1	0.2778
p.G151C	ACH-000855	Esophageal Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	0.2778
p.G151C	KYSE-150	oesophagus	COSMIC	RRHDLSLMS	DEG_APCC_DBOX_1	0.2778
p.M156R	ACH-000122	Leukemia	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	0.1389
p.H157N	ACH-001692	Head and Neck Cancer	CCLE	RRHDLSLMS	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRHDLSLMS

Degron related mutations and impact score

Drug responses associated with TFAP2D mutations

All proteins holding degron of RRHDLSLMS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6R9	Transcription factor AP-2-delta	DEG_APCC_DBOX_1	141:149	RRHDLSLMS	APC,CDC20,FZR1	0.7478	More...