DegronMD

Uniprot ID: Q7Z6R9

Source protein: Transcription factor AP-2-delta

Source gene: TFAP2D

Class: DEG_SPOP_SBC_1

Location: 39:43

E3 ligase: SPOP

DEGRON score: 0.9904

ASA_SCORE: 67.76

COIL: 0.9124

CONS_SCORE: 0.453

DSS_SCORE: 0.2654

HELIX: 0.031

FCONS_SCORE: 1.0017

RIG_SCORE: 0.7185

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T50A	TCGA-85-A512	LUSC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.1389
p.T50A	TCGA-DX-AATS	SARC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.1389
p.T50A	DO45425	LUSC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1389
p.T50A	DO220071	SARC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1389
p.G52A	TCGA-A5-A0G1	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0833
p.G52A	DO42472	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0833
p.P45T	TCGA-AP-A056	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.2778
p.P45T	DO43971	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.L46I	TCGA-AX-A2HC	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.25
p.L46I	DO41572	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.25
p.A39T	TCGA-AZ-4615	COAD	TCGA	AYSSS	DEG_SPOP_SBC_1	0.7139
p.A39T	DO7977	COAD	ICGC	AYSSS	DEG_SPOP_SBC_1	0.7139
p.C29Y	TCGA-NC-A5HN	LUSC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0556
p.C29Y	DO52025	LUSC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.P45S	TCGA-VQ-A8PO	STAD	TCGA	AYSSS	DEG_SPOP_SBC_1	0.2778
p.P45S	DO51773	STAD	ICGC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.S49Y	DO228245	LICA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1667
p.S44C	DO23218	LINC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.3056
p.T53I	DO228349	MALY	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.T53I	SIDM00656	Burkitt's Lymphoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.T53I	SIDM00641	Burkitt's Lymphoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.T53I	ACH-000944	Lymphoma	CCLE	AYSSS	DEG_SPOP_SBC_1	0.0556
p.T53I	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.T51A	DO51477	PACA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1111
p.V33L	DO51954	PRAD	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1667
p.S44F	DO229456	SKCA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.3056
p.Y48C	SIDM00217	Colorectal Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.1944
p.Y48C	ACH-000999	Colon/Colorectal Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	0.1944
p.Y48C	SNU-1040	large_intestine	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.1944
p.V38A	SIDM01753	Gastric Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.3056
p.V38A	ACH-000239	Gastric Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SPOP_SBC_1	286:290	AYSSS	SPOP	0.992	More...
P17661	Desmin	DEG_SPOP_SBC_1	4:8	AYSSS	SPOP	0.9409	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	246:250	AYSSS	SPOP	0.885	More...
Q14191	Werner syndrome ATP-dependent helicase	DEG_SPOP_SBC_1	1137:1141	AYSSS	SPOP	0.5977	More...
Q7Z6R9	Transcription factor AP-2-delta	DEG_SPOP_SBC_1	39:43	AYSSS	SPOP	0.9904	More...
Q7Z739	YTH domain-containing family protein 3	DEG_SPOP_SBC_1	150:154	AYSSS	SPOP	0.9975	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	673:677	AYSSS	SPOP	0.999	More...
A8MTZ7	Uncharacterized protein C12orf71	DEG_SPOP_SBC_1	2:6	AYSSS	SPOP	0.8548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AYSSS

Degron related mutations and impact score

Drug responses associated with TFAP2D mutations

All proteins holding degron of AYSSS