DegronMD

Uniprot ID: O15047

Source protein: Histone-lysine N-methyltransferase SETD1A

Source gene: SETD1A

Class: DEG_SPOP_SBC_1

Location: 286:290

E3 ligase: SPOP

DEGRON score: 0.992

ASA_SCORE: 60.2

COIL: 0.8568

CONS_SCORE: 0.3005

DSS_SCORE: 0.555

HELIX: 0.0906

FCONS_SCORE: 0.9624

RIG_SCORE: 0.6005

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R300Q	TCGA-2W-A8YY	CESC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0556
p.R300Q	DO223732	CESC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.P280H	TCGA-D3-A2JD	SKCM	TCGA	AYSSS	DEG_SPOP_SBC_1	0.1667
p.P280H	DO37543	SKCM	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1667
p.R276Q	TCGA-EO-A22U	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0556
p.R276Q	DO43755	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.R299W	TCGA-L5-A8NM	ESCA	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0833
p.R276W	TCGA-VS-A9UL	CESC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0556
p.R276W	DO51643	CESC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.S289N	DO11854	GBM	ICGC	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S278R	SIDM00179	Melanoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.1111
p.S278R	ACH-002165	Skin Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	0.1111
p.S278R	MZ2-MEL	skin	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SPOP_SBC_1	286:290	AYSSS	SPOP	0.992	More...
P17661	Desmin	DEG_SPOP_SBC_1	4:8	AYSSS	SPOP	0.9409	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	246:250	AYSSS	SPOP	0.885	More...
Q14191	Werner syndrome ATP-dependent helicase	DEG_SPOP_SBC_1	1137:1141	AYSSS	SPOP	0.5977	More...
Q7Z6R9	Transcription factor AP-2-delta	DEG_SPOP_SBC_1	39:43	AYSSS	SPOP	0.9904	More...
Q7Z739	YTH domain-containing family protein 3	DEG_SPOP_SBC_1	150:154	AYSSS	SPOP	0.9975	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	673:677	AYSSS	SPOP	0.999	More...
A8MTZ7	Uncharacterized protein C12orf71	DEG_SPOP_SBC_1	2:6	AYSSS	SPOP	0.8548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons