DegronMD - A8MTZ7(C12orf71)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D13N	TCGA-AN-A046	BRCA	TCGA	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.D13N	DO1285	BRCA	ICGC	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.D13N	SIDM01275	Esophageal Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.D9N	TCGA-BR-A4QL	STAD	TCGA	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.25
p.D9N	DO38723	STAD	ICGC	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.25
p.D9E	DO229035	LICA	ICGC	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.25
p.S14N	DO232224	PBCA	ICGC	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111
p.S14I	SIDM00082	Melanoma	GDSC	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111
p.S14I	ACH-001190	Skin Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111
p.E11Q	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1944
p.E11Q	ACH-000841	Lung Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1944
p.I10V	SIDM01608	Endometrial Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons