DegronMD

Uniprot ID: A8MTZ7

Source protein: Uncharacterized protein C12orf71

Source gene: C12orf71

Class: DEG_SPOP_SBC_1

Location: 2:6

E3 ligase: SPOP

DEGRON score: 0.8548

ASA_SCORE: 104.9

COIL: 0.9684

CONS_SCORE: 0.5285

DSS_SCORE: 0.843

HELIX: 0.0228

FCONS_SCORE: 1.0234

RIG_SCORE: 0.6709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D13N	TCGA-AN-A046	BRCA	TCGA	AYSSS	DEG_SPOP_SBC_1	0.1389
p.D13N	DO1285	BRCA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1389
p.D13N	SIDM01275	Esophageal Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.1389
p.D9N	TCGA-BR-A4QL	STAD	TCGA	AYSSS	DEG_SPOP_SBC_1	0.25
p.D9N	DO38723	STAD	ICGC	AYSSS	DEG_SPOP_SBC_1	0.25
p.D9E	DO229035	LICA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.25
p.S14N	DO232224	PBCA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1111
p.S14I	SIDM00082	Melanoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.1111
p.S14I	ACH-001190	Skin Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	0.1111
p.E11Q	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.1944
p.E11Q	ACH-000841	Lung Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	0.1944
p.I10V	SIDM01608	Endometrial Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SPOP_SBC_1	286:290	AYSSS	SPOP	0.992	More...
P17661	Desmin	DEG_SPOP_SBC_1	4:8	AYSSS	SPOP	0.9409	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	246:250	AYSSS	SPOP	0.885	More...
Q14191	Werner syndrome ATP-dependent helicase	DEG_SPOP_SBC_1	1137:1141	AYSSS	SPOP	0.5977	More...
Q7Z6R9	Transcription factor AP-2-delta	DEG_SPOP_SBC_1	39:43	AYSSS	SPOP	0.9904	More...
Q7Z739	YTH domain-containing family protein 3	DEG_SPOP_SBC_1	150:154	AYSSS	SPOP	0.9975	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	673:677	AYSSS	SPOP	0.999	More...
A8MTZ7	Uncharacterized protein C12orf71	DEG_SPOP_SBC_1	2:6	AYSSS	SPOP	0.8548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons