DegronMD

Uniprot ID: Q00613

Source protein: Heat shock factor protein 1

Source gene: HSF1

Class: DEG_SPOP_SBC_1

Location: 246:250

E3 ligase: SPOP

DEGRON score: 0.885

ASA_SCORE: 77.36

COIL: 0.8244

CONS_SCORE: 0.2911

DSS_SCORE: 0.3388

HELIX: 0.1466

FCONS_SCORE: 0.9298

RIG_SCORE: 0.647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P239H	TCGA-EE-A2GH	SKCM	TCGA	AYSSS	DEG_SPOP_SBC_1	0.1389
p.A254T	TCGA-F1-A448	STAD	TCGA	AYSSS	DEG_SPOP_SBC_1	0.2222
p.A254T	ACH-000179	Lung Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	0.2222
p.S250C	TCGA-GV-A3JZ	BLCA	TCGA	AYSSS	DEG_SPOP_SBC_1	0.7541
p.Y247C	TCGA-W5-AA30	CHOL	TCGA	AYSSS	DEG_SPOP_SBC_1	0.5976
p.P239L	DO234251	ESAD	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1389
p.P239L	ACH-001369	Ovarian Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	0.1389
p.P239L	ACH-002279	Neuroblastoma	CCLE	AYSSS	DEG_SPOP_SBC_1	0.1389
p.S238G	DO35442	PACA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1111
p.R252H	DO36358	PRAD	ICGC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.R252H	DO51795	STAD	ICGC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.S255F	DO37886	SKCM	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1944
p.T258I	DO37996	SKCM	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1111
p.R244G	DO229268	THCA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.G236S	SIDM01040	Ovarian Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.G236S	SIDM00487	Colorectal Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.G236S	ACH-000658	Myeloma	CCLE	AYSSS	DEG_SPOP_SBC_1	0.0556
p.P243L	ACH-001274	Sarcoma	CCLE	AYSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SPOP_SBC_1	286:290	AYSSS	SPOP	0.992	More...
P17661	Desmin	DEG_SPOP_SBC_1	4:8	AYSSS	SPOP	0.9409	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	246:250	AYSSS	SPOP	0.885	More...
Q14191	Werner syndrome ATP-dependent helicase	DEG_SPOP_SBC_1	1137:1141	AYSSS	SPOP	0.5977	More...
Q7Z6R9	Transcription factor AP-2-delta	DEG_SPOP_SBC_1	39:43	AYSSS	SPOP	0.9904	More...
Q7Z739	YTH domain-containing family protein 3	DEG_SPOP_SBC_1	150:154	AYSSS	SPOP	0.9975	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	673:677	AYSSS	SPOP	0.999	More...
A8MTZ7	Uncharacterized protein C12orf71	DEG_SPOP_SBC_1	2:6	AYSSS	SPOP	0.8548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons