DegronMD

Uniprot ID: Q7Z739

Source protein: YTH domain-containing family protein 3

Source gene: YTHDF3

Class: DEG_SPOP_SBC_1

Location: 150:154

E3 ligase: SPOP

DEGRON score: 0.9975

ASA_SCORE: 44.34

COIL: 0.7724

CONS_SCORE: 0.4434

DSS_SCORE: 0.5222

HELIX: 0.1048

FCONS_SCORE: 1.0263

RIG_SCORE: 0.6448

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R163I	TCGA-A5-A0G2	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0833
p.R163I	DO41235	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0833
p.A164D	TCGA-AP-A0LM	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0556
p.A164D	DO43306	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.Q141H	TCGA-AZ-6599	COAD	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0833
p.Q141R	TCGA-BS-A0UV	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.0833
p.Q141R	DO42793	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0833
p.L161I	TCGA-CN-6010	HNSC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.1389
p.L161I	DO14766	HNSC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1389
p.S151N	TCGA-ND-A4WC	UCS	TCGA	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S151N	SIDM00845	Burkitt's Lymphoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S151N	SIDM00461	Acute Myeloid Leukemia	GDSC	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S151N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S151N	SIDM01519	Head and Neck Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S151N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S151N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S151N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.7069
p.S159R	TCGA-OR-A5KB	ACC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.1944
p.S159G	TCGA-VQ-A91S	STAD	TCGA	AYSSS	DEG_SPOP_SBC_1	0.1944
p.A148V	DO227996	COCA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.P155H	DO233764	GACA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.75
p.P146S	DO15334	HNSC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.2222
p.Q156H	DO49733	KIRC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.G142E	DO50875	LICA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1111
p.Q159H	DO28731	OV	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1944
p.R163H	DO219773	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0833
p.G143E	DO43186	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1389
p.S151I	SIDM00699	Small Cell Lung Carcinoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.7341
p.S151I	NCI-H2141	lung	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.7341
p.S147N	ACH-000981	Leukemia	CCLE	AYSSS	DEG_SPOP_SBC_1	0.25
p.S147I	ACH-001138	Lung Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	0.25
p.S148N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.S148N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.S148N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.2778
p.S146I	NCI-H2141	lung	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.2222
p.S146N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.2222
p.S146N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.2222
p.S146N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.2222
p.V157E	CW-2	large_intestine	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.25
p.S148I	NCI-H2141	lung	COSMIC	AYSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SPOP_SBC_1	286:290	AYSSS	SPOP	0.992	More...
P17661	Desmin	DEG_SPOP_SBC_1	4:8	AYSSS	SPOP	0.9409	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	246:250	AYSSS	SPOP	0.885	More...
Q14191	Werner syndrome ATP-dependent helicase	DEG_SPOP_SBC_1	1137:1141	AYSSS	SPOP	0.5977	More...
Q7Z6R9	Transcription factor AP-2-delta	DEG_SPOP_SBC_1	39:43	AYSSS	SPOP	0.9904	More...
Q7Z739	YTH domain-containing family protein 3	DEG_SPOP_SBC_1	150:154	AYSSS	SPOP	0.9975	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	673:677	AYSSS	SPOP	0.999	More...
A8MTZ7	Uncharacterized protein C12orf71	DEG_SPOP_SBC_1	2:6	AYSSS	SPOP	0.8548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AYSSS

Degron related mutations and impact score

Drug responses associated with YTHDF3 mutations

All proteins holding degron of AYSSS