DegronMD

Uniprot ID: Q14191

Source protein: Werner syndrome ATP-dependent helicase

Source gene: WRN

Class: DEG_SPOP_SBC_1

Location: 1137:1141

E3 ligase: SPOP

DEGRON score: 0.5977

ASA_SCORE: 60.46

COIL: 0.6516

CONS_SCORE: 0.28

DSS_SCORE: 0.4387

HELIX: 0.2218

FCONS_SCORE: 0.8768

RIG_SCORE: 0.6688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1140P	TCGA-DI-A1BU	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	0.6752
p.S1140P	DO42023	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	0.6752
p.V1131L	DO222790	COCA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.1667
p.E1151D	DO232224	PBCA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0556
p.Q1150K	DO229227	THCA	ICGC	AYSSS	DEG_SPOP_SBC_1	0.0833
p.S1141L	SIDM00203	Ewing's Sarcoma	GDSC	AYSSS	DEG_SPOP_SBC_1	0.8778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SPOP_SBC_1	286:290	AYSSS	SPOP	0.992	More...
P17661	Desmin	DEG_SPOP_SBC_1	4:8	AYSSS	SPOP	0.9409	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	246:250	AYSSS	SPOP	0.885	More...
Q14191	Werner syndrome ATP-dependent helicase	DEG_SPOP_SBC_1	1137:1141	AYSSS	SPOP	0.5977	More...
Q7Z6R9	Transcription factor AP-2-delta	DEG_SPOP_SBC_1	39:43	AYSSS	SPOP	0.9904	More...
Q7Z739	YTH domain-containing family protein 3	DEG_SPOP_SBC_1	150:154	AYSSS	SPOP	0.9975	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	673:677	AYSSS	SPOP	0.999	More...
A8MTZ7	Uncharacterized protein C12orf71	DEG_SPOP_SBC_1	2:6	AYSSS	SPOP	0.8548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons