DegronMD - Q14191(WRN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1360H	TCGA-73-4658	LUAD	TCGA	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation altering degron motif	0.7688
p.D1360H	DO23663	LUAD	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation altering degron motif	0.7688
p.D1360Y	TCGA-85-8350	LUSC	TCGA	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation altering degron motif	0.7325
p.D1360Y	DO45492	LUSC	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation altering degron motif	0.7325
p.C1374F	TCGA-AX-A0J1	UCEC	TCGA	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.1111
p.C1374F	DO41199	UCEC	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.1111
p.R1373I	TCGA-BS-A0UF	UCEC	TCGA	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.1389
p.R1373I	DO41488	UCEC	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.1389
p.S1140P	TCGA-DI-A1BU	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.6752
p.S1140P	DO42023	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.6752
p.P1095L	TCGA-FS-A1YW	SKCM	TCGA	NLEKLYSYKP	CBL_PTK	1105:1114	Mutation rewiring degron network	0.0556
p.P1095L	DO37734	SKCM	ICGC	NLEKLYSYKP	CBL_PTK	1105:1114	Mutation rewiring degron network	0.0556
p.P1095L	SIDM00003	Melanoma	GDSC	NLEKLYSYKP	CBL_PTK	1105:1114	Mutation rewiring degron network	0.0556
p.P1095L	ACH-000884	Skin Cancer	CCLE	NLEKLYSYKP	CBL_PTK	1105:1114	Mutation rewiring degron network	0.0556
p.P1095L	ACH-002159	Skin Cancer	CCLE	NLEKLYSYKP	CBL_PTK	1105:1114	Mutation rewiring degron network	0.0556
p.P1095L	M14	skin	COSMIC	NLEKLYSYKP	CBL_PTK	1105:1114	Mutation rewiring degron network	0.0556
p.G1362R	DO48384	BLCA	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation altering degron motif	0.7568
p.C1367R	DO227999	COCA	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.3056
p.C1367R	DO229013	COCA	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.3056
p.C1367R	DO229346	LAML	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.3056
p.C1367R	DO229505	LAML	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.3056
p.C1367R	DO230659	LAML	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.3056
p.C1367R	DO231140	LAML	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.3056
p.C1367R	DO228941	LICA	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.3056
p.V1131L	DO222790	COCA	ICGC	AYSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.S1099I	DO229026	LICA	ICGC	NLEKLYSYKP	CBL_PTK	1105:1114	Mutation rewiring degron network	0.1667
p.E1151D	DO232224	PBCA	ICGC	AYSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0556
p.G1121E	DO229465	SKCA	ICGC	NLEKLYSYKP	CBL_PTK	1105:1114	Mutation rewiring degron network	0.1389
p.Q1150K	DO229227	THCA	ICGC	AYSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.S1141L	SIDM00203	Ewing's Sarcoma	GDSC	AYSSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.8778
p.P1376L	SIDM01397	Melanoma	GDSC	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.0556
p.I1352T	ACH-001675	Head and Neck Cancer	CCLE	DSGLQPS	DEG_SCF_TRCP1_1	1360:1366	Mutation rewiring degron network	0.1111

Kaplan plot for WRN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WRN

UniProt ID: Q14191

Entrez ID: 7486

Protein name: Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WRN in