DegronMD

Uniprot ID: Q14191

Source protein: Werner syndrome ATP-dependent helicase

Source gene: WRN

Class: DEG_SCF_TRCP1_1

Location: 1360:1366

E3 ligase: BTRC

DEGRON score: 0.8143

ASA_SCORE: 76.3286

COIL: 0.8774

CONS_SCORE: 0.2633

DSS_SCORE: 0.324

HELIX: 0.0836

FCONS_SCORE: 0.9545

RIG_SCORE: 0.6634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1360H	TCGA-73-4658	LUAD	TCGA	DSGLQPS	DEG_SCF_TRCP1_1	0.7688
p.D1360H	DO23663	LUAD	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.7688
p.D1360Y	TCGA-85-8350	LUSC	TCGA	DSGLQPS	DEG_SCF_TRCP1_1	0.7325
p.D1360Y	DO45492	LUSC	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.7325
p.C1374F	TCGA-AX-A0J1	UCEC	TCGA	DSGLQPS	DEG_SCF_TRCP1_1	0.1111
p.C1374F	DO41199	UCEC	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.1111
p.R1373I	TCGA-BS-A0UF	UCEC	TCGA	DSGLQPS	DEG_SCF_TRCP1_1	0.1389
p.R1373I	DO41488	UCEC	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.1389
p.G1362R	DO48384	BLCA	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.7568
p.C1367R	DO227999	COCA	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.3056
p.C1367R	DO229013	COCA	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.3056
p.C1367R	DO229346	LAML	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.3056
p.C1367R	DO229505	LAML	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.3056
p.C1367R	DO230659	LAML	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.3056
p.C1367R	DO231140	LAML	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.3056
p.C1367R	DO228941	LICA	ICGC	DSGLQPS	DEG_SCF_TRCP1_1	0.3056
p.P1376L	SIDM01397	Melanoma	GDSC	DSGLQPS	DEG_SCF_TRCP1_1	0.0556
p.I1352T	ACH-001675	Head and Neck Cancer	CCLE	DSGLQPS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14191	Werner syndrome ATP-dependent helicase	DEG_SCF_TRCP1_1	1360:1366	DSGLQPS	BTRC	0.8143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons