DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NLEKLYSYKP
Uniprot ID:
Q14191
Source protein:
Werner syndrome ATP-dependent helicase
Source gene:
WRN
Class:
CBL_PTK
Location:
1105:1114
E3 ligase:
CBL
DEGRON score:
0.987
ASA_SCORE:
64.68
COIL:
0.5117
CONS_SCORE:
0.3193
DSS_SCORE:
0.3471
HELIX:
0.3272
FCONS_SCORE:
1.0782
RIG_SCORE:
0.8061
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1095L
TCGA-FS-A1YW
SKCM
TCGA
NLEKLYSYKP
CBL_PTK
0.0556
p.P1095L
DO37734
SKCM
ICGC
NLEKLYSYKP
CBL_PTK
0.0556
p.P1095L
SIDM00003
Melanoma
GDSC
NLEKLYSYKP
CBL_PTK
0.0556
p.P1095L
ACH-000884
Skin Cancer
CCLE
NLEKLYSYKP
CBL_PTK
0.0556
p.P1095L
ACH-002159
Skin Cancer
CCLE
NLEKLYSYKP
CBL_PTK
0.0556
p.P1095L
M14
skin
COSMIC
NLEKLYSYKP
CBL_PTK
0.0556
p.S1099I
DO229026
LICA
ICGC
NLEKLYSYKP
CBL_PTK
0.1667
p.G1121E
DO229465
SKCA
ICGC
NLEKLYSYKP
CBL_PTK
0.1389
Drug responses associated with WRN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NLEKLYSYKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14191
Werner syndrome ATP-dependent helicase
CBL_PTK
1105:1114
NLEKLYSYKP
CBL
0.987
More...
