DegronMD - O15047(SETD1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P606Q	TCGA-12-0778	GBM	TCGA	PPPY	ITCH	614:617	Mutation rewiring degron network	0.1111
p.P606Q	DO11411	GBM	ICGC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.1111
p.P644R	TCGA-28-2502	GBM	TCGA	PPEY	ITCH	643:646	Mutation altering degron motif	0.7512
p.P644R	DO13983	GBM	ICGC	PPEY	ITCH	643:646	Mutation altering degron motif	0.7512
p.R300Q	TCGA-2W-A8YY	CESC	TCGA	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.R300Q	DO223732	CESC	ICGC	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.Q423L	TCGA-34-5231	LUSC	TCGA	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.3056
p.Q423L	DO26772	LUSC	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.3056
p.D422Y	TCGA-37-3792	LUSC	TCGA	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.2778
p.D422Y	DO27192	LUSC	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.2778
p.P638T	TCGA-55-A4DF	LUAD	TCGA	PPEY	ITCH	643:646	Mutation rewiring degron network	0.1944
p.P638T	DO45318	LUAD	ICGC	PPEY	ITCH	643:646	Mutation rewiring degron network	0.1944
p.P914L	TCGA-66-2783	LUSC	TCGA	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation altering degron motif	0.6471
p.P914L	DO26452	LUSC	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation altering degron motif	0.6471
p.P642L	TCGA-AX-A063	UCEC	TCGA	PPEY	ITCH	643:646	Mutation rewiring degron network	0.3056
p.P642L	DO42201	UCEC	ICGC	PPEY	ITCH	643:646	Mutation rewiring degron network	0.3056
p.R419Q	TCGA-AX-A2HD	UCEC	TCGA	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.1944
p.R419Q	TCGA-AX-A2HD	UCEC	TCGA	PPSY	ITCH	406:409	Mutation rewiring degron network	0.0556
p.R419Q	DO42608	UCEC	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.1944
p.R419Q	DO42608	UCEC	ICGC	PPSY	ITCH	406:409	Mutation rewiring degron network	0.0556
p.R1542Q	TCGA-BR-8372	STAD	TCGA	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation altering degron motif	0.6218
p.R1542Q	DO47873	STAD	ICGC	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation altering degron motif	0.6218
p.P280H	TCGA-D3-A2JD	SKCM	TCGA	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1667
p.P280H	DO37543	SKCM	ICGC	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1667
p.P610S	TCGA-D3-A2JF	SKCM	TCGA	PPPY	ITCH	614:617	Mutation rewiring degron network	0.2222
p.P610S	DO38153	SKCM	ICGC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.2222
p.P610L	TCGA-D3-A2JF	SKCM	TCGA	PPPY	ITCH	614:617	Mutation rewiring degron network	0.2222
p.P610L	DO38153	SKCM	ICGC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.2222
p.P428S	TCGA-D3-A2JH	SKCM	TCGA	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.2778
p.P428S	DO47263	SKCM	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.2778
p.S349L	TCGA-DA-A1HW	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.6111
p.S349L	TCGA-GU-A42P	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.6111
p.S349L	TCGA-YD-A9TA	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.6111
p.S349L	DO534	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.6111
p.S349L	DO38129	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.6111
p.S349L	DO219503	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.6111
p.A332T	TCGA-DD-A3A2	LIHC	TCGA	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.A332T	DO44881	LIHC	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.H655P	TCGA-DF-A2KU	UCEC	TCGA	PPEY	ITCH	643:646	Mutation rewiring degron network	0.0833
p.H655P	DO223286	UCEC	ICGC	PPEY	ITCH	643:646	Mutation rewiring degron network	0.0833
p.S341F	TCGA-DK-A6B6	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7982
p.S341F	DO48576	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7982
p.S341F	SIDM00177	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7982
p.P644L	TCGA-EB-A431	SKCM	TCGA	PPEY	ITCH	643:646	Mutation altering degron motif	0.7582
p.P644L	DO37671	SKCM	ICGC	PPEY	ITCH	643:646	Mutation altering degron motif	0.7582
p.P925H	TCGA-EE-A29G	SKCM	TCGA	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1944
p.P925H	DO47303	SKCM	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1944
p.R276Q	TCGA-EO-A22U	UCEC	TCGA	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.R276Q	DO43755	UCEC	ICGC	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.P651S	TCGA-ER-A19D	SKCM	TCGA	PPEY	ITCH	643:646	Mutation rewiring degron network	0.1944
p.P651S	DO37750	SKCM	ICGC	PPEY	ITCH	643:646	Mutation rewiring degron network	0.1944
p.E926D	TCGA-FI-A2D0	UCEC	TCGA	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1667
p.E926D	DO43891	UCEC	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1667
p.S904F	TCGA-FW-A5DX	SKCM	TCGA	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.0556
p.S904F	DO47253	SKCM	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.0556
p.P622S	TCGA-GF-A769	SKCM	TCGA	PPPY	ITCH	614:617	Mutation rewiring degron network	0.1944
p.P622S	DO51255	SKCM	ICGC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.1944
p.S408Y	TCGA-GL-A59R	KIRP	TCGA	PPSY	ITCH	406:409	Mutation altering degron motif	0.6009
p.S408Y	DO44525	KIRP	ICGC	PPSY	ITCH	406:409	Mutation altering degron motif	0.6009
p.R299W	TCGA-L5-A8NM	ESCA	TCGA	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0833
p.A619V	TCGA-NH-A5IV	COAD	TCGA	PPPY	ITCH	614:617	Mutation rewiring degron network	0.2778
p.A619V	DO49095	COAD	ICGC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.2778
p.A619V	ACH-000933	Pancreatic Cancer	CCLE	PPPY	ITCH	614:617	Mutation rewiring degron network	0.2778
p.A329T	TCGA-VQ-A8P2	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0556
p.A329T	DO228542	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0556
p.A329T	DO51761	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0556
p.R276W	TCGA-VS-A9UL	CESC	TCGA	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.R276W	DO51643	CESC	ICGC	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.P415S	TCGA-W3-AA1V	SKCM	TCGA	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.0833
p.P415S	TCGA-W3-AA1V	SKCM	TCGA	PPSY	ITCH	406:409	Mutation rewiring degron network	0.1667
p.P415S	DO51276	SKCM	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.0833
p.P415S	DO51276	SKCM	ICGC	PPSY	ITCH	406:409	Mutation rewiring degron network	0.1667
p.R913H	TCGA-XD-AAUH	PAAD	TCGA	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.3056
p.R913H	DO51721	PAAD	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.3056
p.R1542L	TCGA-XK-AAIW	PRAD	TCGA	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation altering degron motif	0.7316
p.R1542L	DO51407	PRAD	ICGC	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation altering degron motif	0.7316
p.P616S	DO222830	BTCA	ICGC	PPPY	ITCH	614:617	Mutation altering degron motif	0.5641
p.G624V	DO50442	ESAD	ICGC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.1389
p.S352P	DO48290	ESCA	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.5278
p.E919K	DO222705	ESCA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation altering degron motif	0.591
p.P654L	DO233156	GACA	ICGC	PPEY	ITCH	643:646	Mutation rewiring degron network	0.1111
p.P654T	DO233865	GACA	ICGC	PPEY	ITCH	643:646	Mutation rewiring degron network	0.1111
p.S289N	DO11854	GBM	ICGC	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7069
p.R913L	DO228974	LICA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.3056
p.R913L	DO229031	LICA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.3056
p.A432S	DO228978	LICA	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.1667
p.A432S	DO229028	LICA	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.1667
p.A432S	DO229041	LICA	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.1667
p.E930D	DO229038	LICA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.0556
p.G1548V	DO229006	LICA	ICGC	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation altering degron motif	0.6421
p.S352C	DO50864	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation blocking phosphorylation signal	0.5278
p.P654S	DO220857	MELA	ICGC	PPEY	ITCH	643:646	Mutation rewiring degron network	0.1111
p.P917L	DO220885	MELA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation altering degron motif	0.7582
p.P648T	DO222644	MELA	ICGC	PPEY	ITCH	643:646	Mutation rewiring degron network	0.2778
p.P427H	DO27935	ORCA	ICGC	DYR	CBL_MET	424:426	Mutation rewiring degron network	0.3056
p.A339T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7139
p.A339T	ACH-000995	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7139
p.A339T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7139
p.S338Y	SIDM00957	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.S338Y	ACH-000350	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.S338Y	COLO-678	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.A1551T	SIDM00111	Glioma	GDSC	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation rewiring degron network	0.25
p.A1551T	ACH-000232	Brain Cancer	CCLE	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation rewiring degron network	0.25
p.A1551T	ACH-001172	Brain Cancer	CCLE	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation rewiring degron network	0.25
p.A1551T	U251	central nervous system	COSMIC	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation rewiring degron network	0.25
p.P626S	SIDM00656	Burkitt's Lymphoma	GDSC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.0833
p.P626S	SIDM00641	Burkitt's Lymphoma	GDSC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.0833
p.A906V	SIDM00834	Colorectal Carcinoma	GDSC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1111
p.A906V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1111
p.A906V	ACH-000470	Colon/Colorectal Cancer	CCLE	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1111
p.A906V	ACH-001127	Leukemia	CCLE	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1111
p.A906V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1111
p.A906V	SW1463	large intestine	COSMIC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1111
p.P605L	SIDM00596	Endometrial Carcinoma	GDSC	PPPY	ITCH	614:617	Mutation rewiring degron network	0.0833
p.P605L	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	614:617	Mutation rewiring degron network	0.0833
p.P605L	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	614:617	Mutation rewiring degron network	0.0833
p.P605L	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	614:617	Mutation rewiring degron network	0.0833
p.R426Q	SIDM00214	Colorectal Carcinoma	GDSC	DYR	CBL_MET	424:426	Mutation altering degron motif	0.7329
p.R426Q	ACH-000955	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	424:426	Mutation altering degron motif	0.7329
p.R426Q	SNU-407	large intestine	COSMIC	DYR	CBL_MET	424:426	Mutation altering degron motif	0.7329
p.S278R	SIDM00179	Melanoma	GDSC	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1111
p.S278R	ACH-002165	Skin Cancer	CCLE	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1111
p.S278R	MZ2-MEL	skin	COSMIC	AYSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1111
p.E908A	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1667
p.E908A	ACH-000865	Esophageal Cancer	CCLE	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1667
p.E908A	KYSE-450	oesophagus	COSMIC	PSTPAEE	DEG_SCF_FBW7_2	914:920	Mutation rewiring degron network	0.1667
p.E1535K	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation rewiring degron network	0.1944
p.E1535K	ACH-001638	Lymphoma	CCLE	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation rewiring degron network	0.1944
p.E1535K	RC-K8	haematopoietic and lymphoid tissue	COSMIC	QRRLLSAIG	DEG_APCC_DBOX_1	1540:1548	Mutation rewiring degron network	0.1944
p.T331I	ACH-000681	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SETD1A

UniProt ID: O15047

Entrez ID: 9739

Protein name: Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SETD1A in