DegronMD

Uniprot ID: O15047

Source protein: Histone-lysine N-methyltransferase SETD1A

Source gene: SETD1A

Class: DEG_APCC_DBOX_1

Location: 1540:1548

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9658

ASA_SCORE: 81.7111

COIL: 0.2711

CONS_SCORE: 0.5717

DSS_SCORE: 0.3338

HELIX: 0.7211

FCONS_SCORE: 1.2262

RIG_SCORE: 0.7612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1542Q	TCGA-BR-8372	STAD	TCGA	QRRLLSAIG	DEG_APCC_DBOX_1	0.6218
p.R1542Q	DO47873	STAD	ICGC	QRRLLSAIG	DEG_APCC_DBOX_1	0.6218
p.R1542L	TCGA-XK-AAIW	PRAD	TCGA	QRRLLSAIG	DEG_APCC_DBOX_1	0.7316
p.R1542L	DO51407	PRAD	ICGC	QRRLLSAIG	DEG_APCC_DBOX_1	0.7316
p.G1548V	DO229006	LICA	ICGC	QRRLLSAIG	DEG_APCC_DBOX_1	0.6421
p.A1551T	SIDM00111	Glioma	GDSC	QRRLLSAIG	DEG_APCC_DBOX_1	0.25
p.A1551T	ACH-000232	Brain Cancer	CCLE	QRRLLSAIG	DEG_APCC_DBOX_1	0.25
p.A1551T	ACH-001172	Brain Cancer	CCLE	QRRLLSAIG	DEG_APCC_DBOX_1	0.25
p.A1551T	U251	central_nervous_system	COSMIC	QRRLLSAIG	DEG_APCC_DBOX_1	0.25
p.E1535K	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRRLLSAIG	DEG_APCC_DBOX_1	0.1944
p.E1535K	ACH-001638	Lymphoma	CCLE	QRRLLSAIG	DEG_APCC_DBOX_1	0.1944
p.E1535K	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	QRRLLSAIG	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_APCC_DBOX_1	1540:1548	QRRLLSAIG	APC,CDC20,FZR1	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons