DegronMD

Uniprot ID: O15047

Source protein: Histone-lysine N-methyltransferase SETD1A

Source gene: SETD1A

Class: DEG_SCF_FBW7_2

Location: 914:920

E3 ligase: FBXW7

DEGRON score: 0.9783

ASA_SCORE: 98.0857

COIL: 0.8847

CONS_SCORE: 0.3208

DSS_SCORE: 0.8716

HELIX: 0.1104

FCONS_SCORE: 1.0624

RIG_SCORE: 0.4924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P914L	TCGA-66-2783	LUSC	TCGA	PSTPAEE	DEG_SCF_FBW7_2	0.6471
p.P914L	DO26452	LUSC	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.6471
p.P925H	TCGA-EE-A29G	SKCM	TCGA	PSTPAEE	DEG_SCF_FBW7_2	0.1944
p.P925H	DO47303	SKCM	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.1944
p.E926D	TCGA-FI-A2D0	UCEC	TCGA	PSTPAEE	DEG_SCF_FBW7_2	0.1667
p.E926D	DO43891	UCEC	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.1667
p.S904F	TCGA-FW-A5DX	SKCM	TCGA	PSTPAEE	DEG_SCF_FBW7_2	0.0556
p.S904F	DO47253	SKCM	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.0556
p.R913H	TCGA-XD-AAUH	PAAD	TCGA	PSTPAEE	DEG_SCF_FBW7_2	0.3056
p.R913H	DO51721	PAAD	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.3056
p.E919K	DO222705	ESCA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.591
p.R913L	DO228974	LICA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.3056
p.R913L	DO229031	LICA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.3056
p.E930D	DO229038	LICA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.0556
p.P917L	DO220885	MELA	ICGC	PSTPAEE	DEG_SCF_FBW7_2	0.7582
p.A906V	SIDM00834	Colorectal Carcinoma	GDSC	PSTPAEE	DEG_SCF_FBW7_2	0.1111
p.A906V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSTPAEE	DEG_SCF_FBW7_2	0.1111
p.A906V	ACH-000470	Colon/Colorectal Cancer	CCLE	PSTPAEE	DEG_SCF_FBW7_2	0.1111
p.A906V	ACH-001127	Leukemia	CCLE	PSTPAEE	DEG_SCF_FBW7_2	0.1111
p.A906V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPAEE	DEG_SCF_FBW7_2	0.1111
p.A906V	SW1463	large_intestine	COSMIC	PSTPAEE	DEG_SCF_FBW7_2	0.1111
p.E908A	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PSTPAEE	DEG_SCF_FBW7_2	0.1667
p.E908A	ACH-000865	Esophageal Cancer	CCLE	PSTPAEE	DEG_SCF_FBW7_2	0.1667
p.E908A	KYSE-450	oesophagus	COSMIC	PSTPAEE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SCF_FBW7_2	914:920	PSTPAEE	FBXW7	0.9783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons