DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DYR
Uniprot ID:
O15047
Source protein:
Histone-lysine N-methyltransferase SETD1A
Source gene:
SETD1A
Class:
CBL_MET
Location:
424:426
E3 ligase:
CBL
DEGRON score:
0.8226
ASA_SCORE:
109.1667
COIL:
0.9183
CONS_SCORE:
0.285
DSS_SCORE:
0.907
HELIX:
0.0603
FCONS_SCORE:
0.8896
RIG_SCORE:
0.5907
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R426Q
SIDM00214
Colorectal Carcinoma
GDSC
DYR
CBL_MET
0.7329
p.R426Q
ACH-000955
Colon/Colorectal Cancer
CCLE
DYR
CBL_MET
0.7329
p.R426Q
SNU-407
large_intestine
COSMIC
DYR
CBL_MET
0.7329
p.Q423L
TCGA-34-5231
LUSC
TCGA
DYR
CBL_MET
0.3056
p.Q423L
DO26772
LUSC
ICGC
DYR
CBL_MET
0.3056
p.P427H
DO27935
ORCA
ICGC
DYR
CBL_MET
0.3056
p.D422Y
TCGA-37-3792
LUSC
TCGA
DYR
CBL_MET
0.2778
p.D422Y
DO27192
LUSC
ICGC
DYR
CBL_MET
0.2778
p.P428S
TCGA-D3-A2JH
SKCM
TCGA
DYR
CBL_MET
0.2778
p.P428S
DO47263
SKCM
ICGC
DYR
CBL_MET
0.2778
p.R419Q
TCGA-AX-A2HD
UCEC
TCGA
DYR
CBL_MET
0.1944
p.R419Q
DO42608
UCEC
ICGC
DYR
CBL_MET
0.1944
p.A432S
DO228978
LICA
ICGC
DYR
CBL_MET
0.1667
p.A432S
DO229028
LICA
ICGC
DYR
CBL_MET
0.1667
p.A432S
DO229041
LICA
ICGC
DYR
CBL_MET
0.1667
p.P415S
TCGA-W3-AA1V
SKCM
TCGA
DYR
CBL_MET
0.0833
p.P415S
DO51276
SKCM
ICGC
DYR
CBL_MET
0.0833
Showing 1 to 17 of 17 entries
Previous
1
Next
Drug responses associated with SETD1A mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of DYR
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y2I7
1-phosphatidylinositol 3-phosphate 5-kinase
CBL_MET
1154:1156
DYR
CBL
0.9899
More...
P62333
26S proteasome regulatory subunit 10B
CBL_MET
11:13
DYR
CBL
0.5589
More...
Q96A35
39S ribosomal protein L24, mitochondrial
CBL_MET
103:105
DYR
CBL
0.8186
More...
Q9P2N4
A disintegrin and metalloproteinase with thrombospondin motifs 9
CBL_MET
1313:1315
DYR
CBL
0.9337
More...
Q12802
A-kinase anchor protein 13
CBL_MET
823:825
DYR
CBL
0.8159
More...
Q96K21
Abscission/NoCut checkpoint regulator
CBL_MET
348:350
DYR
CBL
0.5257
More...
P40145
Adenylate cyclase type 8
CBL_MET
1148:1150
DYR
CBL
0.7268
More...
P51825
AF4/FMR2 family member 1
CBL_MET
316:318
DYR
CBL
0.9069
More...
Q9P0K7
Ankycorbin
CBL_MET
661:663
DYR
CBL
0.6245
More...
Q6UB99
Ankyrin repeat domain-containing protein 11
CBL_MET
864:866
DYR
CBL
0.5334
More...
Q6UB99
Ankyrin repeat domain-containing protein 11
CBL_MET
899:901
DYR
CBL
0.7809
More...
Q96NW4
Ankyrin repeat domain-containing protein 27
CBL_MET
666:668
DYR
CBL
0.9069
More...
Q8N944
APC membrane recruitment protein 3
CBL_MET
128:130
DYR
CBL
0.9544
More...
Q9BZC7
ATP-binding cassette sub-family A member 2
CBL_MET
1395:1397
DYR
CBL
0.9909
More...
Q08211
ATP-dependent RNA helicase A
CBL_MET
1233:1235
DYR
CBL
0.9757
More...
O00571
ATP-dependent RNA helicase DDX3X
CBL_MET
601:603
DYR
CBL
0.9982
More...
O15523
ATP-dependent RNA helicase DDX3Y
CBL_MET
599:601
DYR
CBL
0.9998
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
56:58
DYR
CBL
0.7315
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
60:62
DYR
CBL
0.9219
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
407:409
DYR
CBL
0.8675
More...
A2AJT9
BCLAF1 and THRAP3 family member 3
CBL_MET
280:282
DYR
CBL
0.8797
More...
Q9NWK9
Box C/D snoRNA protein 1
CBL_MET
277:279
DYR
CBL
0.8233
More...
Q9NSI6
Bromodomain and WD repeat-containing protein 1
CBL_MET
563:565
DYR
CBL
0.9622
More...
P25440
Bromodomain-containing protein 2
CBL_MET
407:409
DYR
CBL
0.9586
More...
Q2TAL6
Brorin
CBL_MET
149:151
DYR
CBL
0.987
More...
Showing 1 to 25 of 231 entries
Previous
1
2
3
4
5
…
10
Next
