DegronMD - Q9HAU0(PLEKHA5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E852K	TCGA-17-Z026	LUAD	TCGA	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation rewiring degron network	0.2222
p.E852K	TCGA-17-Z026	LUAD	TCGA	PESST	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.1667
p.Q850H	TCGA-24-1846	OV	TCGA	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation rewiring degron network	0.1667
p.Q850H	TCGA-24-1846	OV	TCGA	PESST	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.1111
p.Y830N	TCGA-34-5928	LUSC	TCGA	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.1944
p.Y830N	TCGA-3B-A9HS	SARC	TCGA	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.1944
p.E864Q	TCGA-86-A4JF	LUAD	TCGA	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation rewiring degron network	0.25
p.E864Q	TCGA-86-A4JF	LUAD	TCGA	PESST	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.2778
p.R809Q	TCGA-AD-A5EJ	COAD	TCGA	DYR	CBL_MET	803:805	Mutation blocking phosphorylation signal	0.6667
p.T807M	TCGA-AX-A06F	UCEC	TCGA	DYR	CBL_MET	803:805	Mutation blocking phosphorylation signal	0.7222
p.D831Y	TCGA-AX-A0J0	UCEC	TCGA	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.1667
p.T851M	TCGA-AX-A2HD	UCEC	TCGA	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation rewiring degron network	0.1944
p.T851M	TCGA-AX-A2HD	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.1389
p.R858C	TCGA-AX-A3FT	UCEC	TCGA	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation altering degron motif	0.8301
p.R858C	TCGA-AX-A3FT	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	858:862	Mutation altering degron motif	0.8301
p.D826N	TCGA-DK-A6B2	BLCA	TCGA	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.3056
p.Y830H	TCGA-EO-A22R	UCEC	TCGA	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.1944
p.D831G	TCGA-FD-A6TC	BLCA	TCGA	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.1667
p.E829A	TCGA-HT-7606	LGG	TCGA	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.2222
p.R858H	TCGA-ZS-A9CG	LIHC	TCGA	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation altering degron motif	0.8244
p.R858H	TCGA-ZS-A9CG	LIHC	TCGA	PESST	DEG_SPOP_SBC_1	858:862	Mutation altering degron motif	0.8244
p.P832S	DO49760	BLCA	ICGC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation blocking phosphorylation signal	0.5833
p.R866G	DO219020	BLCA	ICGC	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation blocking phosphorylation signal	0.6389
p.R866G	DO219020	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation blocking phosphorylation signal	0.6667
p.E811Q	DO2401	BRCA	ICGC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.0833
p.E811Q	DO2401	BRCA	ICGC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.1667
p.T862M	DO6308	CESC	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation altering degron motif	0.8534
p.T862M	DO50090	COAD	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation altering degron motif	0.8534
p.T862M	DO233254	GACA	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation altering degron motif	0.8534
p.Y848C	DO20919	KIRP	ICGC	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation rewiring degron network	0.1111
p.Y848C	DO20919	KIRP	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.0556
p.M858I	DO219191	LUSC	ICGC	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation altering degron motif	0.7618
p.M858I	DO219191	LUSC	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation altering degron motif	0.7618
p.V869M	DO51720	PAAD	ICGC	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation rewiring degron network	0.1111
p.V869M	DO51720	PAAD	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.1389
p.L872F	DO220056	SARC	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation blocking phosphorylation signal	0.5
p.S824F	DO47419	SKCM	ICGC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation altering degron motif	0.7982
p.P827S	DO51297	SKCM	ICGC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.2778
p.E800D	DO47813	STAD	ICGC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.25
p.R861I	DO43154	UCEC	ICGC	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation altering degron motif	0.8102
p.R861I	DO43154	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation altering degron motif	0.8102
p.P793S	DO52402	UCEC	ICGC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.0556
p.R866I	DO41133	UCEC	ICGC	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation blocking phosphorylation signal	0.6389
p.R866I	DO41133	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	858:862	Mutation blocking phosphorylation signal	0.6667
p.L795S	SIDM00334	Endometrial Carcinoma	GDSC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.1111
p.L795S	ACH-000879	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.1111
p.L795S	MFE-296	endometrium	COSMIC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.1111
p.E824Q	SIDM00938	Breast Carcinoma	GDSC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation altering degron motif	0.6744
p.D798H	SIDM00120	Prostate Carcinoma	GDSC	DYR	CBL_MET	803:805	Mutation substituting flanking lysine	0.3056
p.D798H	ACH-000979	Prostate Cancer	CCLE	DYR	CBL_MET	803:805	Mutation substituting flanking lysine	0.3056
p.D798H	DU-145	prostate	COSMIC	DYR	CBL_MET	803:805	Mutation substituting flanking lysine	0.3056
p.D799G	SIDM00660	Colorectal Carcinoma	GDSC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.2222
p.D799G	ACH-000985	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.2222
p.D799G	LS-411N	large intestine	COSMIC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.2222
p.E817K	SIDM00149	Melanoma	GDSC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.25
p.E817K	LOXIMVI	skin	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.25
p.C808R	SIDM00241	Breast Carcinoma	GDSC	DYR	CBL_MET	803:805	Mutation substituting flanking lysine	0.3611
p.C808R	ACH-002179	Breast Cancer	CCLE	DYR	CBL_MET	803:805	Mutation substituting flanking lysine	0.3611
p.C808R	OCUB-M	breast	COSMIC	DYR	CBL_MET	803:805	Mutation substituting flanking lysine	0.3611
p.R820Q	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation altering degron motif	0.7329
p.R820Q	ACH-001127	Leukemia	CCLE	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation altering degron motif	0.7329
p.R820Q	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation altering degron motif	0.7329
p.E821K	UDSCC2	upper aerodigestive tract	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation altering degron motif	0.591
p.S810L	EVSA-T	breast	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.0556
p.S810L	EVSA-T	breast	COSMIC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.1944
p.E830K	TC-71	bone	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.1944
p.I834K	NY	bone	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.0833
p.P865R	UACC-812	breast	COSMIC	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation blocking phosphorylation signal	0.6667
p.P865R	UACC-812	breast	COSMIC	PESST	DEG_SPOP_SBC_1	858:862	Mutation blocking phosphorylation signal	0.6944
p.I816K	NY	bone	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.2222
p.T832P	C-33-A	cervix	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation blocking phosphorylation signal	0.5833
p.S828L	EVSA-T	breast	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation blocking phosphorylation signal	0.6944
p.A859V	NCI-H2030	lung	COSMIC	PTPESS	DEG_SCF_FBW7_1	856:861	Mutation altering degron motif	0.6936
p.A859V	NCI-H2030	lung	COSMIC	PESST	DEG_SPOP_SBC_1	858:862	Mutation altering degron motif	0.6936
p.A814V	NCI-H2030	lung	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.1667
p.A814V	NCI-H2030	lung	COSMIC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.0833
p.K832E	LoVo	large intestine	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation blocking phosphorylation signal	0.5833
p.E808Q	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	803:805	Mutation substituting flanking lysine	0.3611
p.V826A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DESNGE	DEG_Kelch_Keap1_1	820:825	Mutation rewiring degron network	0.3056
p.T793A	MFE-319	endometrium	COSMIC	DYR	CBL_MET	803:805	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHA5

UniProt ID: Q9HAU0

Entrez ID: 54477

Protein name: Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PLEKHA5 in