DegronMD

Uniprot ID: Q9HAU0

Source protein: Pleckstrin homology domain-containing family A member 5

Source gene: PLEKHA5

Class: DEG_Kelch_Keap1_1

Location: 820:825

E3 ligase: KEAP1

DEGRON score: 0.7698

ASA_SCORE: 91.6833

COIL: 0.6993

CONS_SCORE: 0.4774

DSS_SCORE: 0.6385

HELIX: 0.2847

FCONS_SCORE: 0.8698

RIG_SCORE: 0.6602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y830N	TCGA-34-5928	LUSC	TCGA	DESNGE	DEG_Kelch_Keap1_1	0.1944
p.Y830N	TCGA-3B-A9HS	SARC	TCGA	DESNGE	DEG_Kelch_Keap1_1	0.1944
p.D831Y	TCGA-AX-A0J0	UCEC	TCGA	DESNGE	DEG_Kelch_Keap1_1	0.1667
p.D826N	TCGA-DK-A6B2	BLCA	TCGA	DESNGE	DEG_Kelch_Keap1_1	0.3056
p.Y830H	TCGA-EO-A22R	UCEC	TCGA	DESNGE	DEG_Kelch_Keap1_1	0.1944
p.D831G	TCGA-FD-A6TC	BLCA	TCGA	DESNGE	DEG_Kelch_Keap1_1	0.1667
p.E829A	TCGA-HT-7606	LGG	TCGA	DESNGE	DEG_Kelch_Keap1_1	0.2222
p.P832S	DO49760	BLCA	ICGC	DESNGE	DEG_Kelch_Keap1_1	0.5833
p.E811Q	DO2401	BRCA	ICGC	DESNGE	DEG_Kelch_Keap1_1	0.0833
p.S824F	DO47419	SKCM	ICGC	DESNGE	DEG_Kelch_Keap1_1	0.7982
p.P827S	DO51297	SKCM	ICGC	DESNGE	DEG_Kelch_Keap1_1	0.2778
p.E824Q	SIDM00938	Breast Carcinoma	GDSC	DESNGE	DEG_Kelch_Keap1_1	0.6744
p.E817K	SIDM00149	Melanoma	GDSC	DESNGE	DEG_Kelch_Keap1_1	0.25
p.E817K	LOXIMVI	skin	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.25
p.R820Q	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DESNGE	DEG_Kelch_Keap1_1	0.7329
p.R820Q	ACH-001127	Leukemia	CCLE	DESNGE	DEG_Kelch_Keap1_1	0.7329
p.R820Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.7329
p.E821K	UDSCC2	upper_aerodigestive_tract	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.591
p.S810L	EVSA-T	breast	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.0556
p.E830K	TC-71	bone	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.1944
p.I834K	NY	bone	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.0833
p.I816K	NY	bone	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.2222
p.T832P	C-33-A	cervix	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.5833
p.S828L	EVSA-T	breast	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.6944
p.A814V	NCI-H2030	lung	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.1667
p.K832E	LoVo	large_intestine	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.5833
p.V826A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DESNGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_Kelch_Keap1_1	820:825	DESNGE	KEAP1	0.7698	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DESNGE

Degron related mutations and impact score

Drug responses associated with PLEKHA5 mutations

All proteins holding degron of DESNGE