DegronMD

Uniprot ID: Q9HAU0

Source protein: Pleckstrin homology domain-containing family A member 5

Source gene: PLEKHA5

Class: DEG_SCF_FBW7_1

Location: 856:861

E3 ligase: FBXW7

DEGRON score: 0.9925

ASA_SCORE: 88.4667

COIL: 0.8772

CONS_SCORE: 0.4534

DSS_SCORE: 0.4962

HELIX: 0.0772

FCONS_SCORE: 1.0704

RIG_SCORE: 0.6372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E852K	TCGA-17-Z026	LUAD	TCGA	PTPESS	DEG_SCF_FBW7_1	0.2222
p.Q850H	TCGA-24-1846	OV	TCGA	PTPESS	DEG_SCF_FBW7_1	0.1667
p.E864Q	TCGA-86-A4JF	LUAD	TCGA	PTPESS	DEG_SCF_FBW7_1	0.25
p.T851M	TCGA-AX-A2HD	UCEC	TCGA	PTPESS	DEG_SCF_FBW7_1	0.1944
p.R858C	TCGA-AX-A3FT	UCEC	TCGA	PTPESS	DEG_SCF_FBW7_1	0.8301
p.R858H	TCGA-ZS-A9CG	LIHC	TCGA	PTPESS	DEG_SCF_FBW7_1	0.8244
p.R866G	DO219020	BLCA	ICGC	PTPESS	DEG_SCF_FBW7_1	0.6389
p.Y848C	DO20919	KIRP	ICGC	PTPESS	DEG_SCF_FBW7_1	0.1111
p.M858I	DO219191	LUSC	ICGC	PTPESS	DEG_SCF_FBW7_1	0.7618
p.V869M	DO51720	PAAD	ICGC	PTPESS	DEG_SCF_FBW7_1	0.1111
p.R861I	DO43154	UCEC	ICGC	PTPESS	DEG_SCF_FBW7_1	0.8102
p.R866I	DO41133	UCEC	ICGC	PTPESS	DEG_SCF_FBW7_1	0.6389
p.P865R	UACC-812	breast	COSMIC	PTPESS	DEG_SCF_FBW7_1	0.6667
p.A859V	NCI-H2030	lung	COSMIC	PTPESS	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SCF_FBW7_1	856:861	PTPESS	FBXW7	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons