DegronMD

Uniprot ID: Q9HAU0

Source protein: Pleckstrin homology domain-containing family A member 5

Source gene: PLEKHA5

Class: DEG_SPOP_SBC_1

Location: 858:862

E3 ligase: SPOP

DEGRON score: 0.9895

ASA_SCORE: 90.52

COIL: 0.8362

CONS_SCORE: 0.4586

DSS_SCORE: 0.4953

HELIX: 0.1122

FCONS_SCORE: 1.1096

RIG_SCORE: 0.6654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E852K	TCGA-17-Z026	LUAD	TCGA	PESST	DEG_SPOP_SBC_1	0.1667
p.Q850H	TCGA-24-1846	OV	TCGA	PESST	DEG_SPOP_SBC_1	0.1111
p.E864Q	TCGA-86-A4JF	LUAD	TCGA	PESST	DEG_SPOP_SBC_1	0.2778
p.T851M	TCGA-AX-A2HD	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.1389
p.R858C	TCGA-AX-A3FT	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.8301
p.R858H	TCGA-ZS-A9CG	LIHC	TCGA	PESST	DEG_SPOP_SBC_1	0.8244
p.R866G	DO219020	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	0.6667
p.T862M	DO6308	CESC	ICGC	PESST	DEG_SPOP_SBC_1	0.8534
p.T862M	DO50090	COAD	ICGC	PESST	DEG_SPOP_SBC_1	0.8534
p.T862M	DO233254	GACA	ICGC	PESST	DEG_SPOP_SBC_1	0.8534
p.Y848C	DO20919	KIRP	ICGC	PESST	DEG_SPOP_SBC_1	0.0556
p.M858I	DO219191	LUSC	ICGC	PESST	DEG_SPOP_SBC_1	0.7618
p.V869M	DO51720	PAAD	ICGC	PESST	DEG_SPOP_SBC_1	0.1389
p.L872F	DO220056	SARC	ICGC	PESST	DEG_SPOP_SBC_1	0.5
p.R861I	DO43154	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.8102
p.R866I	DO41133	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.6667
p.P865R	UACC-812	breast	COSMIC	PESST	DEG_SPOP_SBC_1	0.6944
p.A859V	NCI-H2030	lung	COSMIC	PESST	DEG_SPOP_SBC_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons