DegronMD

Uniprot ID: Q9P206

Source protein: Uncharacterized protein KIAA1522

Source gene: KIAA1522

Class: DEG_SPOP_SBC_1

Location: 383:387

E3 ligase: SPOP

DEGRON score: 0.9636

ASA_SCORE: 101.44

COIL: 0.9318

CONS_SCORE: 0.4773

DSS_SCORE: 0.7789

HELIX: 0.0404

FCONS_SCORE: 0.9694

RIG_SCORE: 0.5455

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A388T	TCGA-AD-6889	COAD	TCGA	PESST	DEG_SPOP_SBC_1	0.3056
p.R379H	TCGA-AJ-A3EK	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.6667
p.R375H	TCGA-E6-A2P9	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.1111
p.R391H	TCGA-S9-A7R1	LGG	TCGA	PESST	DEG_SPOP_SBC_1	0.2222
p.S379F	DO51906	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	0.6667
p.S375F	DO49902	CESC	ICGC	PESST	DEG_SPOP_SBC_1	0.1111
p.S389I	DO229038	LICA	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.S374F	DO22905	LIHC	ICGC	PESST	DEG_SPOP_SBC_1	0.0833
p.P396T	DO23740	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	0.0833
p.P383L	DO51193	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	0.7582
p.P383Q	DO229275	THCA	ICGC	PESST	DEG_SPOP_SBC_1	0.7035
p.S391N	DO41361	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.2222
p.L377P	SIDM00537	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.1667
p.L377P	GP5d	large_intestine	COSMIC	PESST	DEG_SPOP_SBC_1	0.1667
p.T387M	NCI-H211	lung	COSMIC	PESST	DEG_SPOP_SBC_1	0.7423
p.N390H	DU-145	prostate	COSMIC	PESST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons