DegronMD

Uniprot ID: Q12967

Source protein: Ral guanine nucleotide dissociation stimulator

Source gene: RALGDS

Class: DEG_SPOP_SBC_1

Location: 60:64

E3 ligase: SPOP

DEGRON score: 0.7712

ASA_SCORE: 80.08

COIL: 0.8692

CONS_SCORE: 0.4235

DSS_SCORE: 0.5728

HELIX: 0.0518

FCONS_SCORE: 1.0405

RIG_SCORE: 0.6938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L53V	TCGA-S5-A6DX	BLCA	TCGA	PESST	DEG_SPOP_SBC_1	0.1389
p.L53V	DO51903	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	0.1389
p.E71Q	DO51612	CESC	ICGC	PESST	DEG_SPOP_SBC_1	0.1389
p.N51S	DO7930	COAD	ICGC	PESST	DEG_SPOP_SBC_1	0.0833
p.T65M	DO230343	COCA	ICGC	PESST	DEG_SPOP_SBC_1	0.3056
p.T65M	DO38192	STAD	ICGC	PESST	DEG_SPOP_SBC_1	0.3056
p.T65M	DO43274	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.3056
p.A62D	DO12058	GBM	ICGC	PESST	DEG_SPOP_SBC_1	0.7793
p.P56L	DO228925	LICA	ICGC	PESST	DEG_SPOP_SBC_1	0.2222
p.G67E	DO36675	READ	ICGC	PESST	DEG_SPOP_SBC_1	0.25
p.H57Y	DO37671	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	0.25
p.P71S	DO219452	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	0.1389
p.A69S	DO51761	STAD	ICGC	PESST	DEG_SPOP_SBC_1	0.1944
p.T55A	DO43755	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.1944
p.A55T	SIDM01293	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.1944
p.G68S	SIDM00537	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.2222
p.G74R	SIDM00641	Burkitt's Lymphoma	GDSC	PESST	DEG_SPOP_SBC_1	0.0556
p.G74R	ACH-000944	Lymphoma	CCLE	PESST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons