DegronMD

Uniprot ID: Q8NA72

Source protein: Centrosomal protein POC5

Source gene: POC5

Class: DEG_SPOP_SBC_1

Location: 545:549

E3 ligase: SPOP

DEGRON score: 0.993

ASA_SCORE: 101.16

COIL: 0.9394

CONS_SCORE: 0.3275

DSS_SCORE: 0.5996

HELIX: 0.0398

FCONS_SCORE: 0.8895

RIG_SCORE: 0.6503

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R558I	TCGA-17-Z022	LUAD	TCGA	PESST	DEG_SPOP_SBC_1	0.0833
p.T549I	TCGA-AJ-A3BH	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.7078
p.S550L	TCGA-DS-A1OD	CESC	TCGA	PESST	DEG_SPOP_SBC_1	0.3056
p.S539T	DO222874	COCA	ICGC	PESST	DEG_SPOP_SBC_1	0.1667
p.H536L	DO45094	LIRI	ICGC	PESST	DEG_SPOP_SBC_1	0.0833
p.A551S	SIDM00259	Neuroblastoma	GDSC	PESST	DEG_SPOP_SBC_1	0.2778
p.A551S	NB10	autonomic_ganglia	COSMIC	PESST	DEG_SPOP_SBC_1	0.2778
p.R541Q	SIDM00865	Small Cell Lung Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.2222
p.R541Q	DMS-114	lung	COSMIC	PESST	DEG_SPOP_SBC_1	0.2222
p.K544I	ACH-000958	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.3056
p.K544I	SW48	large_intestine	COSMIC	PESST	DEG_SPOP_SBC_1	0.3056
p.K547I	SW48	large_intestine	COSMIC	PESST	DEG_SPOP_SBC_1	0.7531

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons