DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_SPOP_SBC_1

Location: 2345:2349

E3 ligase: SPOP

DEGRON score: 0.9601

ASA_SCORE: 100.22

COIL: 0.9394

CONS_SCORE: 0.4047

DSS_SCORE: 0.7699

HELIX: 0.0404

FCONS_SCORE: 1.2356

RIG_SCORE: 0.5954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2346D	TCGA-39-5036	LUSC	TCGA	PESST	DEG_SPOP_SBC_1	0.5647
p.E2346D	DO27508	LUSC	ICGC	PESST	DEG_SPOP_SBC_1	0.5647
p.Y2344C	TCGA-3G-AB0T	THYM	TCGA	PESST	DEG_SPOP_SBC_1	0.3056
p.A2355T	TCGA-BR-4184	STAD	TCGA	PESST	DEG_SPOP_SBC_1	0.1667
p.A2355T	DO38328	STAD	ICGC	PESST	DEG_SPOP_SBC_1	0.1667
p.E2337K	TCGA-DA-A1IC	SKCM	TCGA	PESST	DEG_SPOP_SBC_1	0.1111
p.E2337K	DO37430	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	0.1111
p.R2342G	DO233913	GACA	ICGC	PESST	DEG_SPOP_SBC_1	0.25
p.E2337G	SIDM00489	Oral Cavity Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.1111
p.E2337G	ACH-002043	Head and Neck Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.1111
p.E2337G	Ca9-22	upper_aerodigestive_tract	COSMIC	PESST	DEG_SPOP_SBC_1	0.1111
p.R2342M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.25
p.R2342M	ACH-000826	Lung Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.25
p.R2342M	CAL-12T	lung	COSMIC	PESST	DEG_SPOP_SBC_1	0.25
p.E2354A	ACH-000982	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons