DegronMD - O94986(CEP152)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1248S	TCGA-38-4632	LUAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.25
p.D1703V	TCGA-3B-A9HT	SARC	TCGA	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation altering degron motif	0.6674
p.D1703V	DO219934	SARC	ICGC	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation altering degron motif	0.6674
p.D619Y	TCGA-60-2724	LUSC	TCGA	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1667
p.D619Y	TCGA-AP-A0LM	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1667
p.P1243L	TCGA-77-6842	LUSC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6471
p.P1242L	TCGA-A5-A0G1	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.7582
p.T1351P	TCGA-A5-A0G2	UCEC	TCGA	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation altering degron motif	0.8142
p.A1250G	TCGA-AA-A02R	COAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1944
p.S1354C	TCGA-AC-A6IW	BRCA	TCGA	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation altering degron motif	0.643
p.P1514H	TCGA-AP-A051	UCEC	TCGA	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation altering degron motif	0.6583
p.P1514H	DO42673	UCEC	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation altering degron motif	0.6583
p.R1244M	TCGA-AP-A051	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.7521
p.P603T	TCGA-AZ-4315	COAD	TCGA	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1667
p.Q1698P	TCGA-B8-A54H	KIRC	TCGA	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation rewiring degron network	0.3056
p.Q1698P	DO49733	KIRC	ICGC	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation rewiring degron network	0.3056
p.S1247P	TCGA-BS-A0UF	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation blocking phosphorylation signal	0.7222
p.A1343T	TCGA-CD-A4MG	STAD	TCGA	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation rewiring degron network	0.1944
p.G1249E	TCGA-CH-5753	PRAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.2222
p.C1255S	TCGA-CM-5341	COAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.0556
p.D1703H	TCGA-DS-A1OB	CESC	TCGA	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation altering degron motif	0.6577
p.D1703H	DO6323	CESC	ICGC	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation altering degron motif	0.6577
p.P1693Q	TCGA-EE-A2MS	SKCM	TCGA	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation rewiring degron network	0.1667
p.P1693Q	DO37567	SKCM	ICGC	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation rewiring degron network	0.1667
p.K1231T	TCGA-EO-A22X	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation blocking ubiquitination signal	0.5833
p.K604N	TCGA-EY-A1G8	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	609:613	Mutation substituting flanking lysine	0.3056
p.K1229N	TCGA-F5-6814	READ	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation blocking ubiquitination signal	0.5278
p.A1346T	TCGA-FI-A2D5	UCEC	TCGA	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation rewiring degron network	0.2778
p.A1346T	SIDM00217	Colorectal Carcinoma	GDSC	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation rewiring degron network	0.2778
p.A1346T	ACH-000999	Colon/Colorectal Cancer	CCLE	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation rewiring degron network	0.2778
p.A1346T	SNU-1040	large intestine	COSMIC	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation rewiring degron network	0.2778
p.P1514L	TCGA-FW-A3R5	SKCM	TCGA	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation altering degron motif	0.6471
p.P1514L	DO37406	SKCM	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation altering degron motif	0.6471
p.C1255F	TCGA-G4-6628	COAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.0556
p.S1517L	TCGA-VQ-AA6F	STAD	TCGA	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation rewiring degron network	0.2778
p.S1517L	DO222393	STAD	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation rewiring degron network	0.2778
p.L1502S	DO230315	COCA	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation rewiring degron network	0.1667
p.S1700G	DO222576	COCA	ICGC	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation altering degron motif	0.6993
p.E1239V	DO52184	LIHC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.7693
p.A602T	DO25797	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	609:613	Mutation substituting flanking lysine	0.25
p.L601F	DO25797	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1111
p.E1236D	DO45451	LUSC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.2778
p.G1701C	DO32391	OV	ICGC	DSGFDS	DEG_SCF_TRCP1_1	1699:1704	Mutation altering degron motif	0.76
p.L611F	DO37819	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	609:613	Mutation altering degron motif	0.6981
p.A1250T	DO48009	STAD	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1944
p.T1501I	DO234011	THCA	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation rewiring degron network	0.1389
p.R617I	DO43041	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.2222
p.R617I	DO43907	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.2222
p.K1241N	DO41644	UCEC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6918
p.A1253T	DO41331	UCEC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1111
p.A1253T	SNU-1040	large intestine	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1111
p.P1243A	SIDM00321	Ovarian Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00993	Plasma Cell Myeloma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00064	Hepatocellular Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00553	Acute Myeloid Leukemia	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00294	Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00290	Gastric Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00252	Biliary Tract Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00299	Other Sarcomas	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00365	Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00613	Glioblastoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM00279	Gastric Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SIDM01619	Endometrial Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	KY821	haematopoietic and lymphoid tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	ECC12	stomach	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	TYK-nu	ovary	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	TGBC1TKB	biliary tract	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	AMO-1	haematopoietic and lymphoid tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	MFH-ino	soft tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	HLE	liver	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	SBC-1	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	KALS-1	central nervous system	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	RERF-LC-KJ	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	LU-135	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	HGC-27	stomach	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	TE-11	oesophagus	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.P1243A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6392
p.R1509G	SIDM00001	Other Blood Cancers	GDSC	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation altering degron motif	0.6457
p.R1509G	ACH-000405	Leukemia	CCLE	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation altering degron motif	0.6457
p.P1352L	SIDM00545	Melanoma	GDSC	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation altering degron motif	0.7582
p.P1352L	ACH-000987	Skin Cancer	CCLE	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation altering degron motif	0.7582
p.P1352L	Mewo	skin	COSMIC	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation altering degron motif	0.7582
p.R1525H	SIDM00801	Melanoma	GDSC	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation rewiring degron network	0.0556
p.R1525H	ACH-000008	Skin Cancer	CCLE	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation rewiring degron network	0.0556
p.R1525H	ACH-000014	Metastasis	CCLE	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation rewiring degron network	0.0556
p.R1525H	A101D	skin	COSMIC	PRCTPGPS	DEG_SCF_FBW7_1	1508:1515	Mutation rewiring degron network	0.0556
p.S1340R	SIDM00706	Small Cell Lung Carcinoma	GDSC	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation rewiring degron network	0.1111
p.S1340R	ACH-000290	Lung Cancer	CCLE	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation rewiring degron network	0.1111
p.S1340R	NCI-H209	lung	COSMIC	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation rewiring degron network	0.1111
p.V616L	SIDM00706	Small Cell Lung Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.25
p.V616L	ACH-000290	Lung Cancer	CCLE	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.25
p.V616L	NCI-H209	lung	COSMIC	PESST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.25
p.G1249R	ACH-000820	Colon/Colorectal Cancer	CCLE	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.2222
p.S1247R	NCI-H209	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation blocking phosphorylation signal	0.7222
p.C1351R	HuO-3N1	bone	COSMIC	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation altering degron motif	0.8301
p.Q1353P	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	LLETPISS	DEG_SCF_FBW7_1	1348:1355	Mutation altering degron motif	0.7035
p.Q1249E	NCI-H1944	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP152

UniProt ID: O94986

Entrez ID: 22995

Protein name: Centrosomal protein of 152 kDa (Cep152)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP152 in