DegronMD

Uniprot ID: O94986

Source protein: Centrosomal protein of 152 kDa

Source gene: CEP152

Class: DEG_SCF_FBW7_1

Location: 1238:1245

E3 ligase: FBXW7

DEGRON score: 0.9489

ASA_SCORE: 106.95

COIL: 0.7233

CONS_SCORE: 0.5188

DSS_SCORE: 0.324

HELIX: 0.2726

FCONS_SCORE: 1.0018

RIG_SCORE: 0.7492

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1239V	DO52184	LIHC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	0.7693
p.P1242L	TCGA-A5-A0G1	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.7582
p.R1244M	TCGA-AP-A051	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.7521
p.S1247P	TCGA-BS-A0UF	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.7222
p.S1247R	NCI-H209	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.7222
p.K1241N	DO41644	UCEC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	0.6918
p.P1243L	TCGA-77-6842	LUSC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.6471
p.P1243A	SIDM00321	Ovarian Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00993	Plasma Cell Myeloma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00064	Hepatocellular Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00553	Acute Myeloid Leukemia	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00294	Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00290	Gastric Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00252	Biliary Tract Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00299	Other Sarcomas	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00365	Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00613	Glioblastoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00279	Gastric Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM01619	Endometrial Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	ECC12	stomach	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	TYK-nu	ovary	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392

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Drug responses associated with CEP152 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LCKTPPRS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SCF_FBW7_1	1238:1245	LCKTPPRS	FBXW7	0.9489	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LCKTPPRS

Degron related mutations and impact score

Drug responses associated with CEP152 mutations

All proteins holding degron of LCKTPPRS