DegronMD

Uniprot ID: O94986

Source protein: Centrosomal protein of 152 kDa

Source gene: CEP152

Class: DEG_SCF_FBW7_1

Location: 1238:1245

E3 ligase: FBXW7

DEGRON score: 0.9489

ASA_SCORE: 106.95

COIL: 0.7233

CONS_SCORE: 0.5188

DSS_SCORE: 0.324

HELIX: 0.2726

FCONS_SCORE: 1.0018

RIG_SCORE: 0.7492

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1248S	TCGA-38-4632	LUAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.25
p.P1243L	TCGA-77-6842	LUSC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.6471
p.P1242L	TCGA-A5-A0G1	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.7582
p.A1250G	TCGA-AA-A02R	COAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.1944
p.R1244M	TCGA-AP-A051	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.7521
p.S1247P	TCGA-BS-A0UF	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.7222
p.G1249E	TCGA-CH-5753	PRAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.2222
p.C1255S	TCGA-CM-5341	COAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.0556
p.K1231T	TCGA-EO-A22X	UCEC	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.5833
p.K1229N	TCGA-F5-6814	READ	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.5278
p.C1255F	TCGA-G4-6628	COAD	TCGA	LCKTPPRS	DEG_SCF_FBW7_1	0.0556
p.E1239V	DO52184	LIHC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	0.7693
p.E1236D	DO45451	LUSC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	0.2778
p.A1250T	DO48009	STAD	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	0.1944
p.K1241N	DO41644	UCEC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	0.6918
p.A1253T	DO41331	UCEC	ICGC	LCKTPPRS	DEG_SCF_FBW7_1	0.1111
p.A1253T	SNU-1040	large_intestine	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.1111
p.P1243A	SIDM00321	Ovarian Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00993	Plasma Cell Myeloma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00064	Hepatocellular Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00553	Acute Myeloid Leukemia	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00294	Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00290	Gastric Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00252	Biliary Tract Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00299	Other Sarcomas	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00365	Small Cell Lung Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00613	Glioblastoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM00279	Gastric Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SIDM01619	Endometrial Carcinoma	GDSC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	ECC12	stomach	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	TYK-nu	ovary	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	TGBC1TKB	biliary_tract	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	MFH-ino	soft_tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	HLE	liver	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	SBC-1	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	KALS-1	central_nervous_system	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	RERF-LC-KJ	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	LU-135	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	HGC-27	stomach	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	TE-11	oesophagus	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.P1243A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.6392
p.G1249R	ACH-000820	Colon/Colorectal Cancer	CCLE	LCKTPPRS	DEG_SCF_FBW7_1	0.2222
p.S1247R	NCI-H209	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.7222
p.Q1249E	NCI-H1944	lung	COSMIC	LCKTPPRS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LCKTPPRS

Degron related mutations and impact score

Drug responses associated with CEP152 mutations

All proteins holding degron of LCKTPPRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SCF_FBW7_1	1238:1245	LCKTPPRS	FBXW7	0.9489	More...