DegronMD

Uniprot ID: O94986

Source protein: Centrosomal protein of 152 kDa

Source gene: CEP152

Class: DEG_SCF_FBW7_1

Location: 1348:1355

E3 ligase: FBXW7

DEGRON score: 0.9484

ASA_SCORE: 100.1875

COIL: 0.714

CONS_SCORE: 0.2985

DSS_SCORE: 0.454

HELIX: 0.2696

FCONS_SCORE: 0.9585

RIG_SCORE: 0.7349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1351P	TCGA-A5-A0G2	UCEC	TCGA	LLETPISS	DEG_SCF_FBW7_1	0.8142
p.S1354C	TCGA-AC-A6IW	BRCA	TCGA	LLETPISS	DEG_SCF_FBW7_1	0.643
p.A1343T	TCGA-CD-A4MG	STAD	TCGA	LLETPISS	DEG_SCF_FBW7_1	0.1944
p.A1346T	TCGA-FI-A2D5	UCEC	TCGA	LLETPISS	DEG_SCF_FBW7_1	0.2778
p.A1346T	SIDM00217	Colorectal Carcinoma	GDSC	LLETPISS	DEG_SCF_FBW7_1	0.2778
p.A1346T	ACH-000999	Colon/Colorectal Cancer	CCLE	LLETPISS	DEG_SCF_FBW7_1	0.2778
p.A1346T	SNU-1040	large_intestine	COSMIC	LLETPISS	DEG_SCF_FBW7_1	0.2778
p.P1352L	SIDM00545	Melanoma	GDSC	LLETPISS	DEG_SCF_FBW7_1	0.7582
p.P1352L	ACH-000987	Skin Cancer	CCLE	LLETPISS	DEG_SCF_FBW7_1	0.7582
p.P1352L	Mewo	skin	COSMIC	LLETPISS	DEG_SCF_FBW7_1	0.7582
p.S1340R	SIDM00706	Small Cell Lung Carcinoma	GDSC	LLETPISS	DEG_SCF_FBW7_1	0.1111
p.S1340R	ACH-000290	Lung Cancer	CCLE	LLETPISS	DEG_SCF_FBW7_1	0.1111
p.S1340R	NCI-H209	lung	COSMIC	LLETPISS	DEG_SCF_FBW7_1	0.1111
p.C1351R	HuO-3N1	bone	COSMIC	LLETPISS	DEG_SCF_FBW7_1	0.8301
p.Q1353P	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	LLETPISS	DEG_SCF_FBW7_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SCF_FBW7_1	1348:1355	LLETPISS	FBXW7	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons