DegronMD

Uniprot ID: O94986

Source protein: Centrosomal protein of 152 kDa

Source gene: CEP152

Class: DEG_SPOP_SBC_1

Location: 609:613

E3 ligase: SPOP

DEGRON score: 0.7195

ASA_SCORE: 105.34

COIL: 0.7614

CONS_SCORE: 0.3539

DSS_SCORE: 0.5277

HELIX: 0.2254

FCONS_SCORE: 0.9625

RIG_SCORE: 0.6953

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D619Y	TCGA-60-2724	LUSC	TCGA	PESST	DEG_SPOP_SBC_1	0.1667
p.D619Y	TCGA-AP-A0LM	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.1667
p.P603T	TCGA-AZ-4315	COAD	TCGA	PESST	DEG_SPOP_SBC_1	0.1667
p.K604N	TCGA-EY-A1G8	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.3056
p.A602T	DO25797	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	0.25
p.L601F	DO25797	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	0.1111
p.L611F	DO37819	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	0.6981
p.R617I	DO43041	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.2222
p.R617I	DO43907	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.2222
p.V616L	SIDM00706	Small Cell Lung Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.25
p.V616L	ACH-000290	Lung Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.25
p.V616L	NCI-H209	lung	COSMIC	PESST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons