DegronMD

Uniprot ID: Q5QJE6

Source protein: Deoxynucleotidyltransferase terminal-interacting protein 2

Source gene: DNTTIP2

Class: DEG_SPOP_SBC_1

Location: 35:39

E3 ligase: SPOP

DEGRON score: 0.7551

ASA_SCORE: 90.66

COIL: 0.8354

CONS_SCORE: 0.3683

DSS_SCORE: 0.6843

HELIX: 0.0532

FCONS_SCORE: 1.0165

RIG_SCORE: 0.5656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R44Q	TCGA-19-5956	GBM	TCGA	PESST	DEG_SPOP_SBC_1	0.1944
p.R44Q	DO13863	GBM	ICGC	PESST	DEG_SPOP_SBC_1	0.1944
p.A33V	TCGA-AP-A0LM	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.2778
p.A33V	TCGA-B5-A3FC	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.2778
p.A33V	DO233764	GACA	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.A33V	DO43306	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.A33V	DO41871	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.T39A	TCGA-B5-A3FA	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.825
p.T39A	DO52402	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.825
p.T39A	SIDM00217	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.825
p.T39A	ACH-000999	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.825
p.T39A	SNU-1040	large_intestine	COSMIC	PESST	DEG_SPOP_SBC_1	0.825
p.H34N	TCGA-BP-4961	KIRC	TCGA	PESST	DEG_SPOP_SBC_1	0.3056
p.H34N	DO17811	KIRC	ICGC	PESST	DEG_SPOP_SBC_1	0.3056
p.D42H	TCGA-CV-A45Q	HNSC	TCGA	PESST	DEG_SPOP_SBC_1	0.25
p.D42H	DO49060	HNSC	ICGC	PESST	DEG_SPOP_SBC_1	0.25
p.S37G	TCGA-DD-AACF	LIHC	TCGA	PESST	DEG_SPOP_SBC_1	0.6993
p.S37G	DO52201	LIHC	ICGC	PESST	DEG_SPOP_SBC_1	0.6993
p.S37G	SIDM00537	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.6993
p.S37G	ACH-001345	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.6993
p.S37G	GP5d	large_intestine	COSMIC	PESST	DEG_SPOP_SBC_1	0.6993
p.A43S	SIDM01445	Gastric Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons