DegronMD - P54725(RAD23A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P130L	TCGA-21-1079	LUSC	TCGA	APTTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6471
p.P130L	DO26846	LUSC	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6471
p.P107H	TCGA-D3-A1QA	SKCM	TCGA	PESST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1667
p.P107H	DO47469	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1667
p.E126Q	TCGA-DK-A2I4	BLCA	TCGA	APTTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.25
p.E126Q	DO465	BLCA	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.25
p.A129T	TCGA-DU-6392	LGG	TCGA	APTTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7139
p.A129T	DO227763	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7139
p.A129T	DO22237	LGG	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7139
p.P124Q	TCGA-EE-A2MD	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.P124Q	DO37851	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.S143C	TCGA-IR-A3LA	CESC	TCGA	APTTS	DEG_SPOP_SBC_1	129:133	Mutation blocking phosphorylation signal	0.5
p.S143C	DO44377	CESC	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation blocking phosphorylation signal	0.5
p.K122R	DO940	BOCA	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation blocking ubiquitination signal	0.5833
p.P104L	DO233869	GACA	ICGC	PESST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.P104L	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PESST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.P104L	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PESST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.T131A	DO52365	LUSC	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7139
p.A95D	DO50727	ORCA	ICGC	PESST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.2778
p.R119I	DO30340	OV	ICGC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0556
p.T132M	SIDM01951	Colorectal Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.8534
p.S100A	SIDM00585	Hepatocellular Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7588
p.S100A	SIDM01433	Kidney Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7588
p.S100A	ACH-000317	Kidney Cancer	CCLE	PESST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7588
p.S100A	ACH-000480	Liver Cancer	CCLE	PESST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7588
p.S100A	HuH-7	liver	COSMIC	PESST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7588

Kaplan plot for RAD23A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAD23A

UniProt ID: P54725

Entrez ID: 5886

Protein name: UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAD23A in