DegronMD

Uniprot ID: P54725

Source protein: UV excision repair protein RAD23 homolog A

Source gene: RAD23A

Class: DEG_SPOP_SBC_1

Location: 97:101

E3 ligase: SPOP

DEGRON score: 0.9802

ASA_SCORE: 90.24

COIL: 0.9104

CONS_SCORE: 0.3185

DSS_SCORE: 0.7508

HELIX: 0.0518

FCONS_SCORE: 1.0261

RIG_SCORE: 0.5298

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P107H	TCGA-D3-A1QA	SKCM	TCGA	PESST	DEG_SPOP_SBC_1	0.1667
p.P107H	DO47469	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	0.1667
p.P104L	DO233869	GACA	ICGC	PESST	DEG_SPOP_SBC_1	0.25
p.P104L	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PESST	DEG_SPOP_SBC_1	0.25
p.P104L	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PESST	DEG_SPOP_SBC_1	0.25
p.A95D	DO50727	ORCA	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.S100A	SIDM00585	Hepatocellular Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.7588
p.S100A	SIDM01433	Kidney Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.7588
p.S100A	ACH-000317	Kidney Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.7588
p.S100A	ACH-000480	Liver Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.7588
p.S100A	HuH-7	liver	COSMIC	PESST	DEG_SPOP_SBC_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons