DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PESST
Uniprot ID:
Q5QP82
Source protein:
DDB1- and CUL4-associated factor 10
Source gene:
DCAF10
Class:
DEG_SPOP_SBC_1
Location:
77:81
E3 ligase:
SPOP
DEGRON score:
0.8874
ASA_SCORE:
71.48
COIL:
0.6816
CONS_SCORE:
0.1771
DSS_SCORE:
0.8092
HELIX:
0.0626
FCONS_SCORE:
0.7087
RIG_SCORE:
0.5001
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DCAF10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PESST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94986
Centrosomal protein of 152 kDa
DEG_SPOP_SBC_1
609:613
PESST
SPOP
0.7195
More...
P54725
UV excision repair protein RAD23 homolog A
DEG_SPOP_SBC_1
97:101
PESST
SPOP
0.9802
More...
Q12967
Ral guanine nucleotide dissociation stimulator
DEG_SPOP_SBC_1
60:64
PESST
SPOP
0.7712
More...
Q49A26
Putative oxidoreductase GLYR1
DEG_SPOP_SBC_1
184:188
PESST
SPOP
0.9378
More...
Q5QJE6
Deoxynucleotidyltransferase terminal-interacting protein 2
DEG_SPOP_SBC_1
35:39
PESST
SPOP
0.7551
More...
Q5QP82
DDB1- and CUL4-associated factor 10
DEG_SPOP_SBC_1
77:81
PESST
SPOP
0.8874
More...
Q86UK5
Limbin
DEG_SPOP_SBC_1
71:75
PESST
SPOP
0.9462
More...
Q8IWN7
Retinitis pigmentosa 1-like 1 protein
DEG_SPOP_SBC_1
2345:2349
PESST
SPOP
0.9601
More...
Q8NA72
Centrosomal protein POC5
DEG_SPOP_SBC_1
545:549
PESST
SPOP
0.993
More...
Q9HAU0
Pleckstrin homology domain-containing family A member 5
DEG_SPOP_SBC_1
858:862
PESST
SPOP
0.9895
More...
Q9P206
Uncharacterized protein KIAA1522
DEG_SPOP_SBC_1
383:387
PESST
SPOP
0.9636
More...