DegronMD - Q8NA72(POC5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R558I	TCGA-17-Z022	LUAD	TCGA	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.0833
p.T134A	TCGA-32-2494	GBM	TCGA	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.25
p.T134A	DO11998	GBM	ICGC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.25
p.T549I	TCGA-AJ-A3BH	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.7078
p.H36Y	TCGA-AX-A05Z	UCEC	TCGA	IVTPNIE	DEG_SCF_FBW7_2	39:45	Mutation rewiring degron network	0.25
p.A38V	TCGA-AX-A2HC	UCEC	TCGA	IVTPNIE	DEG_SCF_FBW7_2	39:45	Mutation rewiring degron network	0.3056
p.S136Y	TCGA-B5-A0JY	UCEC	TCGA	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.S136Y	TCGA-F5-6814	READ	TCGA	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.S550L	TCGA-DS-A1OD	CESC	TCGA	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.3056
p.S122I	DO1643	BRCA	ICGC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.D123N	DO7801	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.S539T	DO222874	COCA	ICGC	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1667
p.P132Q	DO229041	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.H536L	DO45094	LIRI	ICGC	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.0833
p.L33S	DO47331	SKCM	ICGC	IVTPNIE	DEG_SCF_FBW7_2	39:45	Mutation rewiring degron network	0.1667
p.L126S	SIDM00712	Non-Cancerous	GDSC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.L126S	SIDM00713	Mesothelioma	GDSC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.L126S	ACH-000153	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.A551S	SIDM00259	Neuroblastoma	GDSC	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.2778
p.A551S	NB10	autonomic ganglia	COSMIC	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.2778
p.R541Q	SIDM00865	Small Cell Lung Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.2222
p.R541Q	DMS-114	lung	COSMIC	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.2222
p.A127G	SIDM00699	Small Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.754
p.A127G	NCI-H2141	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.754
p.S136F	SIDM00118	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.S136F	HCC2998	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.K544I	ACH-000958	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.3056
p.K544I	SW48	large intestine	COSMIC	PESST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.3056
p.G141A	SK-HEP-1	liver	COSMIC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556
p.G141A	COLO-792	skin	COSMIC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556
p.G141A	MIA-PaCa-2	pancreas	COSMIC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556
p.K547I	SW48	large intestine	COSMIC	PESST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.7531
p.G123C	DND-41	haematopoietic and lymphoid tissue	COSMIC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.I119L	HT-115	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POC5

UniProt ID: Q8NA72

Entrez ID: 134359

Protein name: Centrosomal protein POC5 (Protein of centriole 5) (hPOC5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POC5 in