DegronMD

Uniprot ID: Q8NA72

Source protein: Centrosomal protein POC5

Source gene: POC5

Class: DEG_SCF_FBW7_2

Location: 39:45

E3 ligase: FBXW7

DEGRON score: 0.7201

ASA_SCORE: 62.4571

COIL: 0.6601

CONS_SCORE: 0.4363

DSS_SCORE: 0.3864

HELIX: 0.0547

FCONS_SCORE: 1.0389

RIG_SCORE: 0.7812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H36Y	TCGA-AX-A05Z	UCEC	TCGA	IVTPNIE	DEG_SCF_FBW7_2	0.25
p.A38V	TCGA-AX-A2HC	UCEC	TCGA	IVTPNIE	DEG_SCF_FBW7_2	0.3056
p.L33S	DO47331	SKCM	ICGC	IVTPNIE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NA72	Centrosomal protein POC5	DEG_SCF_FBW7_2	39:45	IVTPNIE	FBXW7	0.7201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons