DegronMD - Q49A26(GLYR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G195R	TCGA-EE-A29N	SKCM	TCGA	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.G195R	DO229063	LICA	ICGC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.G195R	DO38001	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.P174L	TCGA-FW-A3R5	SKCM	TCGA	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.P174L	DO37406	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.D180H	TCGA-G6-A8L8	KIRC	TCGA	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2222
p.E178K	TCGA-P3-A6T3	HNSC	TCGA	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.E178K	DO49055	HNSC	ICGC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.P184L	TCGA-XK-AAIW	PRAD	TCGA	PESST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7582
p.P184L	DO51407	PRAD	ICGC	PESST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7582
p.A194T	DO227657	COCA	ICGC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.T182I	DO222875	MELA	ICGC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2778
p.A194V	SIDM00216	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.A194V	ACH-000989	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.A194V	SNU-175	large intestine	COSMIC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.A198T	SIDM00151	Ovarian Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.A198T	ACH-000966	Ovarian Cancer	CCLE	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.A198T	IGROV-1	ovary	COSMIC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.P196S	SIDM00177	Melanoma	GDSC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.P196S	ACH-002338	Skin Cancer	CCLE	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.P196S	ACH-002510	Skin Cancer	CCLE	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.P196L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.P196L	ACH-000918	Leukemia	CCLE	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.P196L	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.F191L	SNU-81	large intestine	COSMIC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.M197V	Detroit562	upper aerodigestive tract	COSMIC	PESST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.D186G	PF-382	haematopoietic and lymphoid tissue	COSMIC	PESST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7198

Kaplan plot for GLYR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLYR1

UniProt ID: Q49A26

Entrez ID: 84656

Protein name: Putative oxidoreductase GLYR1 (EC 1.-.-.-) (3-hydroxyisobutyrate dehydrogenase-like protein) (Cytokine-like nuclear factor N-PAC) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLYR1 in