DegronMD

Uniprot ID: Q49A26

Source protein: Putative oxidoreductase GLYR1

Source gene: GLYR1

Class: DEG_SPOP_SBC_1

Location: 184:188

E3 ligase: SPOP

DEGRON score: 0.9378

ASA_SCORE: 82.32

COIL: 0.7934

CONS_SCORE: 0.118

DSS_SCORE: 0.6523

HELIX: 0.1738

FCONS_SCORE: 1.0143

RIG_SCORE: 0.6943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G195R	TCGA-EE-A29N	SKCM	TCGA	PESST	DEG_SPOP_SBC_1	0.1389
p.G195R	DO229063	LICA	ICGC	PESST	DEG_SPOP_SBC_1	0.1389
p.G195R	DO38001	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	0.1389
p.P174L	TCGA-FW-A3R5	SKCM	TCGA	PESST	DEG_SPOP_SBC_1	0.0556
p.P174L	DO37406	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	0.0556
p.D180H	TCGA-G6-A8L8	KIRC	TCGA	PESST	DEG_SPOP_SBC_1	0.2222
p.E178K	TCGA-P3-A6T3	HNSC	TCGA	PESST	DEG_SPOP_SBC_1	0.1667
p.E178K	DO49055	HNSC	ICGC	PESST	DEG_SPOP_SBC_1	0.1667
p.P184L	TCGA-XK-AAIW	PRAD	TCGA	PESST	DEG_SPOP_SBC_1	0.7582
p.P184L	DO51407	PRAD	ICGC	PESST	DEG_SPOP_SBC_1	0.7582
p.A194T	DO227657	COCA	ICGC	PESST	DEG_SPOP_SBC_1	0.1667
p.T182I	DO222875	MELA	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.A194V	SIDM00216	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.1667
p.A194V	ACH-000989	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.1667
p.A194V	SNU-175	large_intestine	COSMIC	PESST	DEG_SPOP_SBC_1	0.1667
p.A198T	SIDM00151	Ovarian Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	0.0556
p.A198T	ACH-000966	Ovarian Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.0556
p.A198T	IGROV-1	ovary	COSMIC	PESST	DEG_SPOP_SBC_1	0.0556
p.P196S	SIDM00177	Melanoma	GDSC	PESST	DEG_SPOP_SBC_1	0.1111
p.P196S	ACH-002338	Skin Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.1111
p.P196S	ACH-002510	Skin Cancer	CCLE	PESST	DEG_SPOP_SBC_1	0.1111
p.P196L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PESST	DEG_SPOP_SBC_1	0.1111
p.P196L	ACH-000918	Leukemia	CCLE	PESST	DEG_SPOP_SBC_1	0.1111
p.P196L	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PESST	DEG_SPOP_SBC_1	0.1111
p.F191L	SNU-81	large_intestine	COSMIC	PESST	DEG_SPOP_SBC_1	0.25
p.M197V	Detroit562	upper_aerodigestive_tract	COSMIC	PESST	DEG_SPOP_SBC_1	0.0833
p.D186G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PESST	DEG_SPOP_SBC_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PESST

Degron related mutations and impact score

Drug responses associated with GLYR1 mutations

All proteins holding degron of PESST