DegronMD

Uniprot ID: Q86UK5

Source protein: Limbin

Source gene: EVC2

Class: DEG_SPOP_SBC_1

Location: 71:75

E3 ligase: SPOP

DEGRON score: 0.9462

ASA_SCORE: 72.12

COIL: 0.759

CONS_SCORE: 0.3011

DSS_SCORE: 0.565

HELIX: 0.1318

FCONS_SCORE: 1.0472

RIG_SCORE: 0.5927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W83C	TCGA-29-2434	OV	TCGA	PESST	DEG_SPOP_SBC_1	0.1111
p.D77E	TCGA-BK-A139	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	0.2778
p.D77E	TCGA-ZF-AA4V	BLCA	TCGA	PESST	DEG_SPOP_SBC_1	0.2778
p.P79S	TCGA-CG-4466	STAD	TCGA	PESST	DEG_SPOP_SBC_1	0.2222
p.P79S	DO38695	STAD	ICGC	PESST	DEG_SPOP_SBC_1	0.2222
p.E63Q	DO48454	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	0.1111
p.G65R	DO477	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	0.1667
p.A69V	DO233259	GACA	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.Q76H	DO233618	GACA	ICGC	PESST	DEG_SPOP_SBC_1	0.3056
p.G70R	DO50970	LICA	ICGC	PESST	DEG_SPOP_SBC_1	0.3056
p.G85E	DO23112	LINC	ICGC	PESST	DEG_SPOP_SBC_1	0.1667
p.R69L	DO24359	LUAD	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.E77D	DO27811	MALY	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.P63S	DO220851	MELA	ICGC	PESST	DEG_SPOP_SBC_1	0.1111
p.T81A	DO51783	STAD	ICGC	PESST	DEG_SPOP_SBC_1	0.1667
p.R69C	DO47903	STAD	ICGC	PESST	DEG_SPOP_SBC_1	0.2778
p.N84H	DO41331	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	0.0833
p.G72W	TE-9	oesophagus	COSMIC	PESST	DEG_SPOP_SBC_1	0.7825
p.G72V	TE-9	oesophagus	COSMIC	PESST	DEG_SPOP_SBC_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SPOP_SBC_1	609:613	PESST	SPOP	0.7195	More...
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	97:101	PESST	SPOP	0.9802	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	60:64	PESST	SPOP	0.7712	More...
Q49A26	Putative oxidoreductase GLYR1	DEG_SPOP_SBC_1	184:188	PESST	SPOP	0.9378	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	35:39	PESST	SPOP	0.7551	More...
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_SPOP_SBC_1	77:81	PESST	SPOP	0.8874	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	71:75	PESST	SPOP	0.9462	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	2345:2349	PESST	SPOP	0.9601	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	545:549	PESST	SPOP	0.993	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	DEG_SPOP_SBC_1	858:862	PESST	SPOP	0.9895	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	383:387	PESST	SPOP	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons