DegronMD - Q12967(RALGDS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G751V	TCGA-86-6851	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.2222
p.R281Q	TCGA-AD-6899	COAD	TCGA	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation rewiring degron network	0.1389
p.N723S	TCGA-AJ-A3BH	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1389
p.N723S	TCGA-FI-A2D5	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1389
p.A266V	TCGA-AJ-A8CW	UCEC	TCGA	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation rewiring degron network	0.3056
p.L277I	TCGA-B5-A1MR	UCEC	TCGA	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation rewiring degron network	0.25
p.E748K	TCGA-BH-A2L8	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.T767M	TCGA-BR-6802	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation blocking phosphorylation signal	0.5556
p.T767M	TCGA-EY-A215	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation blocking phosphorylation signal	0.5556
p.S761P	TCGA-C8-A275	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.2778
p.L53V	TCGA-S5-A6DX	BLCA	TCGA	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1389
p.L53V	DO51903	BLCA	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1389
p.S760P	DO2359	BRCA	ICGC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.3056
p.E71Q	DO51612	CESC	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1389
p.R718H	DO10550	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.2778
p.E279G	DO7849	COAD	ICGC	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation rewiring degron network	0.1944
p.N51S	DO7930	COAD	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.0833
p.T65M	DO230343	COCA	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.3056
p.T65M	DO38192	STAD	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.3056
p.T65M	DO43274	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.3056
p.S272L	DO233267	GACA	ICGC	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation altering degron motif	0.7667
p.V749A	DO13863	GBM	ICGC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1667
p.A62D	DO12058	GBM	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation altering degron motif	0.7793
p.R722C	DO52060	HNSC	ICGC	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1667
p.P56L	DO228925	LICA	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2222
p.F709L	DO46657	PAAD	ICGC	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.25
p.A273D	DO232761	PBCA	ICGC	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation altering degron motif	0.7793
p.G67E	DO36675	READ	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.25
p.Y759C	DO219996	SARC	ICGC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation altering degron motif	0.7087
p.H57Y	DO37671	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.25
p.P274L	DO37931	SKCM	ICGC	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation altering degron motif	0.7582
p.P71S	DO219452	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1389
p.A69S	DO51761	STAD	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1944
p.T766M	DO38332	STAD	ICGC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.T766M	DO42665	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.A716V	DO219773	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.6936
p.A263V	DO41020	UCEC	ICGC	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation rewiring degron network	0.2222
p.L260F	DO41999	UCEC	ICGC	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation rewiring degron network	0.1389
p.T55A	DO43755	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1944
p.V749I	DO41379	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1667
p.A55T	SIDM01293	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1944
p.A712V	SIDM00216	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.5825
p.A712V	ACH-000989	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.5825
p.T766N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.T766N	ACH-002256	Leukemia	CCLE	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.T766N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1389
p.G68S	SIDM00537	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2222
p.G74R	SIDM00641	Burkitt's Lymphoma	GDSC	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.0556
p.G74R	ACH-000944	Lymphoma	CCLE	PESST	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.0556
p.G713S	SIDM01475	Ovarian Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.5882
p.V769M	ACH-000214	Non-Cancerous	CCLE	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0556
p.A706T	ACH-000790	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1667
p.A706T	ACH-001413	Bladder Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1667
p.A706E	ACH-000793	Gastric Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1667
p.D718N	ACH-000874	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.2778
p.V709M	ACH-000974	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.25
p.V709M	ACH-002026	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.25
p.E720G	ACH-000983	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.2222
p.E271K	HPAC	pancreas	COSMIC	LKPTPELE	DEG_SCF_FBW7_2	267:274	Mutation altering degron motif	0.7022
p.T754N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.3056
p.V753M	639-V	urinary tract	COSMIC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation blocking phosphorylation signal	0.7222
p.V753M	DBTRG-05MG	central nervous system	COSMIC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation blocking phosphorylation signal	0.7222
p.T765N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1667
p.T711N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RALGDS

UniProt ID: Q12967

Entrez ID: 5900

Protein name: Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RALGDS in