DegronMD

Uniprot ID: Q12967

Source protein: Ral guanine nucleotide dissociation stimulator

Source gene: RALGDS

Class: DEG_SCF_FBW7_2

Location: 267:274

E3 ligase: FBXW7

DEGRON score: 0.9151

ASA_SCORE: 85.925

COIL: 0.7793

CONS_SCORE: 0.3972

DSS_SCORE: 0.5907

HELIX: 0.1578

FCONS_SCORE: 1.0736

RIG_SCORE: 0.6723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R281Q	TCGA-AD-6899	COAD	TCGA	LKPTPELE	DEG_SCF_FBW7_2	0.1389
p.A266V	TCGA-AJ-A8CW	UCEC	TCGA	LKPTPELE	DEG_SCF_FBW7_2	0.3056
p.L277I	TCGA-B5-A1MR	UCEC	TCGA	LKPTPELE	DEG_SCF_FBW7_2	0.25
p.E279G	DO7849	COAD	ICGC	LKPTPELE	DEG_SCF_FBW7_2	0.1944
p.S272L	DO233267	GACA	ICGC	LKPTPELE	DEG_SCF_FBW7_2	0.7667
p.A273D	DO232761	PBCA	ICGC	LKPTPELE	DEG_SCF_FBW7_2	0.7793
p.P274L	DO37931	SKCM	ICGC	LKPTPELE	DEG_SCF_FBW7_2	0.7582
p.A263V	DO41020	UCEC	ICGC	LKPTPELE	DEG_SCF_FBW7_2	0.2222
p.L260F	DO41999	UCEC	ICGC	LKPTPELE	DEG_SCF_FBW7_2	0.1389
p.E271K	HPAC	pancreas	COSMIC	LKPTPELE	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SCF_FBW7_2	267:274	LKPTPELE	FBXW7	0.9151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons