DegronMD - Q5QJE6(DNTTIP2)

FUNCTION: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147}.

GO - Biological processes (BP): RNA processing [GO:0006396]

GO - Molecular function (MF): RNA binding [GO:0003723]

GO - Cellular component (CC): chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T428M	SIDM00282	Colorectal Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.8534
p.T428M	ACH-000998	Colon/Colorectal Cancer	CCLE	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.8534
p.T428M	CW-2	large intestine	COSMIC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.8534
p.T39A	TCGA-B5-A3FA	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.T39A	DO52402	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.T39A	SIDM00217	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.T39A	ACH-000999	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.T39A	SNU-1040	large intestine	COSMIC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.D423H	SIDM00230	Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	SIDM01042	Breast Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	ACH-001065	Breast Cancer	CCLE	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	ACH-002145	Lung Cancer	CCLE	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	IST-SL2	lung	COSMIC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	EVSA-T	breast	COSMIC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.T433K	DO229032	LICA	ICGC	DTKLYTSAP	CBL_PTK	423:431	Mutation blocking phosphorylation signal	0.7222
p.S429Y	SIDM00214	Colorectal Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.712
p.S429Y	ACH-000955	Colon/Colorectal Cancer	CCLE	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.712
p.S429Y	SNU-407	large intestine	COSMIC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.712
p.P621Q	DO229036	LICA	ICGC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation altering degron motif	0.7035
p.S37G	TCGA-DD-AACF	LIHC	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.6993

Showing 1 to 20 of 103 entries

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Kaplan plot for DNTTIP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNTTIP2

UniProt ID: Q5QJE6

Entrez ID: 30836

Protein name: Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNTTIP2 in