DegronMD - Q5QJE6(DNTTIP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R44Q	TCGA-19-5956	GBM	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1944
p.R44Q	DO13863	GBM	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1944
p.L482M	TCGA-AA-A010	COAD	TCGA	IDTTPGMS	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.0833
p.E421Q	TCGA-AC-A23H	BRCA	TCGA	DTKLYTSAP	CBL_PTK	423:431	Mutation rewiring degron network	0.2778
p.E421Q	DO2401	BRCA	ICGC	DTKLYTSAP	CBL_PTK	423:431	Mutation rewiring degron network	0.2778
p.A33V	TCGA-AP-A0LM	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.A33V	TCGA-B5-A3FC	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.A33V	DO233764	GACA	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.A33V	DO43306	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.A33V	DO41871	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.Y504H	TCGA-AX-A05Z	UCEC	TCGA	IDTTPGMS	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1667
p.Y504H	DO40884	UCEC	ICGC	IDTTPGMS	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1667
p.F195L	TCGA-AX-A2HC	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1944
p.F195L	DO41572	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1944
p.T39A	TCGA-B5-A3FA	UCEC	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.T39A	DO52402	UCEC	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.T39A	SIDM00217	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.T39A	ACH-000999	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.T39A	SNU-1040	large intestine	COSMIC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.825
p.H34N	TCGA-BP-4961	KIRC	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.3056
p.H34N	DO17811	KIRC	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.3056
p.I221S	TCGA-BQ-5876	KIRP	TCGA	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.1111
p.I221S	DO20759	KIRP	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.1111
p.D238G	TCGA-CD-A4MG	STAD	TCGA	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.2778
p.D238G	DO48009	STAD	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.2778
p.D485N	TCGA-CR-7368	HNSC	TCGA	IDTTPGMS	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1667
p.D485N	DO14167	HNSC	ICGC	IDTTPGMS	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1667
p.D42H	TCGA-CV-A45Q	HNSC	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.D42H	DO49060	HNSC	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.R123M	TCGA-D3-A1Q1	SKCM	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	126:133	Mutation rewiring degron network	0.25
p.R123M	DO37445	SKCM	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	126:133	Mutation rewiring degron network	0.25
p.T200A	TCGA-D8-A1XK	BRCA	TCGA	AETSS	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.0556
p.T200A	DO4749	BRCA	ICGC	AETSS	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.0556
p.S37G	TCGA-DD-AACF	LIHC	TCGA	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.6993
p.S37G	DO52201	LIHC	ICGC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.6993
p.S37G	SIDM00537	Colorectal Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.6993
p.S37G	ACH-001345	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.6993
p.S37G	GP5d	large intestine	COSMIC	PESST	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.6993
p.P620S	TCGA-DV-A4W0	KIRC	TCGA	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation altering degron motif	0.5641
p.P620S	DO219235	KIRC	ICGC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation altering degron motif	0.5641
p.N502K	TCGA-EO-A3B0	UCEC	TCGA	IDTTPGMS	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.2222
p.N502K	DO219773	UCEC	ICGC	IDTTPGMS	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.2222
p.K132N	TCGA-ER-A2NH	SKCM	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	126:133	Mutation altering degron motif	0.5806
p.K132N	DO47683	SKCM	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	126:133	Mutation altering degron motif	0.5806
p.E226Q	TCGA-JW-A5VL	CESC	TCGA	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.25
p.E226Q	DO49976	CESC	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.25
p.I609V	TCGA-LN-A5U6	ESCA	TCGA	VITPDFE	DEG_SCF_FBW7_2	608:614	Mutation altering degron motif	0.5965
p.Q228H	TCGA-ZF-A9RF	BLCA	TCGA	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.3056
p.Q228H	DO219074	BLCA	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.3056
p.D240N	DO48414	BLCA	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.2222
p.R633H	DO50393	ESAD	ICGC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation rewiring degron network	0.0833
p.R633H	SIDM00777	Colorectal Carcinoma	GDSC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation rewiring degron network	0.0833
p.R633H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation rewiring degron network	0.0833
p.R633H	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation rewiring degron network	0.0833
p.E187Q	DO234335	ESAD	ICGC	AETSS	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.5633
p.V608I	DO233731	GACA	ICGC	VITPDFE	DEG_SCF_FBW7_2	608:614	Mutation altering degron motif	0.5965
p.V608I	DO233885	GACA	ICGC	VITPDFE	DEG_SCF_FBW7_2	608:614	Mutation altering degron motif	0.5965
p.V608I	DO51130	PRAD	ICGC	VITPDFE	DEG_SCF_FBW7_2	608:614	Mutation altering degron motif	0.5965
p.V608I	ACH-001960	Bile Duct Cancer	CCLE	VITPDFE	DEG_SCF_FBW7_2	608:614	Mutation altering degron motif	0.5965
p.S623G	DO233885	GACA	ICGC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation altering degron motif	0.6993
p.P223Q	DO229019	LICA	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	229:236	Mutation rewiring degron network	0.1667
p.T433K	DO229032	LICA	ICGC	DTKLYTSAP	CBL_PTK	423:431	Mutation blocking phosphorylation signal	0.7222
p.P621Q	DO229036	LICA	ICGC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation altering degron motif	0.7035
p.G416E	DO50970	LICA	ICGC	DTKLYTSAP	CBL_PTK	423:431	Mutation rewiring degron network	0.1389
p.A430V	SIDM00672	Hepatocellular Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00656	Burkitt's Lymphoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00654	Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00690	Head and Neck Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00879	Breast Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00849	Kidney Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00875	Breast Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM01133	Other Solid Cancers	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00808	Burkitt's Lymphoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM01173	Rhabdomyosarcoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM00641	Burkitt's Lymphoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM01254	Burkitt's Lymphoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.A430V	SIDM01525	Acute Myeloid Leukemia	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.5825
p.Y627C	SIDM00334	Endometrial Carcinoma	GDSC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation rewiring degron network	0.25
p.Y627C	ACH-000879	Endometrial/Uterine Cancer	CCLE	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation rewiring degron network	0.25
p.D423H	SIDM00230	Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	SIDM01042	Breast Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	ACH-001065	Breast Cancer	CCLE	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	ACH-002145	Lung Cancer	CCLE	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	IST-SL2	lung	COSMIC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.D423H	EVSA-T	breast	COSMIC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.7688
p.T428M	SIDM00282	Colorectal Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.8534
p.T428M	ACH-000998	Colon/Colorectal Cancer	CCLE	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.8534
p.T428M	CW-2	large intestine	COSMIC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.8534
p.K615N	SIDM01081	Oral Cavity Carcinoma	GDSC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation substituting flanking lysine	0.3333
p.K615N	ACH-000238	Head and Neck Cancer	CCLE	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation substituting flanking lysine	0.3333
p.K615N	SCC-4	upper aerodigestive tract	COSMIC	VPPYSE	LIG_APCC_ABBA_1	619:624	Mutation substituting flanking lysine	0.3333
p.S429Y	SIDM00214	Colorectal Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.712
p.S429Y	ACH-000955	Colon/Colorectal Cancer	CCLE	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.712
p.S429Y	SNU-407	large intestine	COSMIC	DTKLYTSAP	CBL_PTK	423:431	Mutation altering degron motif	0.712
p.K599N	SIDM00628	Breast Carcinoma	GDSC	VITPDFE	DEG_SCF_FBW7_2	608:614	Mutation substituting flanking lysine	0.1944
p.K599N	ACH-000849	Breast Cancer	CCLE	VITPDFE	DEG_SCF_FBW7_2	608:614	Mutation substituting flanking lysine	0.1944
p.K599N	MDA-MB-468	breast	COSMIC	VITPDFE	DEG_SCF_FBW7_2	608:614	Mutation substituting flanking lysine	0.1944
p.A43S	SIDM01445	Gastric Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNTTIP2

UniProt ID: Q5QJE6

Entrez ID: 30836

Protein name: Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNTTIP2 in