DegronMD

Uniprot ID: Q5QJE6

Source protein: Deoxynucleotidyltransferase terminal-interacting protein 2

Source gene: DNTTIP2

Class: DEG_SCF_FBW7_1

Location: 491:498

E3 ligase: FBXW7

DEGRON score: 0.9637

ASA_SCORE: 70.1875

COIL: 0.806

CONS_SCORE: 0.4412

DSS_SCORE: 0.3241

HELIX: 0.0655

FCONS_SCORE: 1.1078

RIG_SCORE: 0.7642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L482M	TCGA-AA-A010	COAD	TCGA	IDTTPGMS	DEG_SCF_FBW7_1	0.0833
p.Y504H	TCGA-AX-A05Z	UCEC	TCGA	IDTTPGMS	DEG_SCF_FBW7_1	0.1667
p.Y504H	DO40884	UCEC	ICGC	IDTTPGMS	DEG_SCF_FBW7_1	0.1667
p.D485N	TCGA-CR-7368	HNSC	TCGA	IDTTPGMS	DEG_SCF_FBW7_1	0.1667
p.D485N	DO14167	HNSC	ICGC	IDTTPGMS	DEG_SCF_FBW7_1	0.1667
p.N502K	TCGA-EO-A3B0	UCEC	TCGA	IDTTPGMS	DEG_SCF_FBW7_1	0.2222
p.N502K	DO219773	UCEC	ICGC	IDTTPGMS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SCF_FBW7_1	491:498	IDTTPGMS	FBXW7	0.9637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons