DegronMD

Uniprot ID: Q5QJE6

Source protein: Deoxynucleotidyltransferase terminal-interacting protein 2

Source gene: DNTTIP2

Class: DEG_SPOP_SBC_1

Location: 186:190

E3 ligase: SPOP

DEGRON score: 0.989

ASA_SCORE: 71.42

COIL: 0.6904

CONS_SCORE: 0.425

DSS_SCORE: 0.5438

HELIX: 0.2142

FCONS_SCORE: 1.1044

RIG_SCORE: 0.6313

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F195L	TCGA-AX-A2HC	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.1944
p.F195L	DO41572	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.T200A	TCGA-D8-A1XK	BRCA	TCGA	AETSS	DEG_SPOP_SBC_1	0.0556
p.T200A	DO4749	BRCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.0556
p.E187Q	DO234335	ESAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.5633

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons