DegronMD - Q8N307(MUC20)

FUNCTION: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. {ECO:0000269|PubMed:15314156}.

GO - Biological processes (BP): hepatocyte growth factor receptor signaling pathway [GO:0048012]

GO - Molecular function (MF): identical protein binding [GO:0042802]

GO - Cellular component (CC): apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
SRDPLPSVP	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Mucin-20	603:611	More..
PVITPSWS	DEG_SCF_FBW7_1	FBXW7	Mucin-20	394:401	More..
VGTPLPT	DEG_SCF_FBW7_1	FBXW7	Mucin-20	496:502	More..
AETSS	DEG_SPOP_SBC_1	SPOP	Mucin-20	62:66	More..
AHTST	DEG_SPOP_SBC_1	SPOP	Mucin-20	163:167	More..
ASSTS	DEG_SPOP_SBC_1	SPOP	Mucin-20	452:456	More..
PPTTT	DEG_SPOP_SBC_1	SPOP	Mucin-20	611:615	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S456F	TCGA-A5-A0G2	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7982
p.S456F	DO41235	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7982
p.A396S	Becker	central nervous system	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.7588
p.P394A	DO44097	BLCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.7503
p.T161I	TCGA-43-8116	LUSC	TCGA	AHTST	DEG_SPOP_SBC_1	163:167	Mutation blocking phosphorylation signal	0.7222
p.T161I	DO27349	LUSC	ICGC	AHTST	DEG_SPOP_SBC_1	163:167	Mutation blocking phosphorylation signal	0.7222
p.A452T	DO219878	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7139
p.T453A	HT-115	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7139
p.V496F	TCGA-EO-A22X	UCEC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.7068
p.V496F	DO43907	UCEC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.7068
p.S609F	DO222567	MELA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6871
p.S399F	Hep_3B2_1-7	NS	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.6871
p.P499S	TCGA-HU-A4H8	STAD	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6752
p.P499S	DO47869	STAD	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6752
p.P611S	DO234177	ESAD	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.6752
p.S66P	DO229505	LAML	ICGC	AETSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.6752
p.D605A	DO48410	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO228483	BRCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO224731	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO222782	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682

Showing 1 to 20 of 212 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MUC20

UniProt ID: Q8N307

Entrez ID: 200958

Protein name: Mucin-20 (MUC-20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MUC20 in