DegronMD - Q8N307(MUC20)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P612Q	TCGA-06-5416	GBM	TCGA	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.5924
p.P612Q	DO10880	GBM	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.5924
p.P501S	TCGA-19-4065	GBM	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.5641
p.P501S	DO11591	GBM	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.5641
p.P501S	SIDM00040	Gastric Carcinoma	GDSC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.5641
p.P501S	ACH-002202	Gastric Cancer	CCLE	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.5641
p.P501S	TMK-1	stomach	COSMIC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.5641
p.T161I	TCGA-43-8116	LUSC	TCGA	AHTST	DEG_SPOP_SBC_1	163:167	Mutation blocking phosphorylation signal	0.7222
p.T161I	DO27349	LUSC	ICGC	AHTST	DEG_SPOP_SBC_1	163:167	Mutation blocking phosphorylation signal	0.7222
p.R619Q	TCGA-4Z-AA7R	BLCA	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R619Q	TCGA-4Z-AA7R	BLCA	TCGA	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2222
p.R619Q	TCGA-K4-A54R	BLCA	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R619Q	TCGA-K4-A54R	BLCA	TCGA	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2222
p.R619Q	DO51866	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R619Q	DO51866	BLCA	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2222
p.R619Q	DO48611	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R619Q	DO48611	BLCA	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2222
p.R619Q	DO222455	ESCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R619Q	DO222455	ESCA	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2222
p.R619Q	SIDM00963	Breast Carcinoma	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R619Q	SIDM00963	Breast Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2222
p.R619Q	BT-474	breast	COSMIC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R619Q	BT-474	breast	COSMIC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2222
p.G497E	TCGA-56-8629	LUSC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6087
p.G497E	DO45451	LUSC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6087
p.P606R	TCGA-63-A5MU	LUSC	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6401
p.P606R	DO219165	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6401
p.D593E	TCGA-A5-A0G1	UCEC	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0556
p.D593E	DO42472	UCEC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0556
p.S456F	TCGA-A5-A0G2	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7982
p.S456F	DO41235	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7982
p.P501H	TCGA-AA-3492	COAD	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6583
p.P501H	DO8224	COAD	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6583
p.D390N	TCGA-AA-A010	COAD	TCGA	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2222
p.E466K	TCGA-AC-A23H	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.E466K	DO2401	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.E466K	DO221548	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.E466K	DO232532	PBCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.E466K	DO218861	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.E466K	ACH-001132	Lymphoma	CCLE	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.L461M	TCGA-AJ-A3EK	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1944
p.L461M	DO41584	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1944
p.A387T	TCGA-B5-A0JY	UCEC	TCGA	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1389
p.A387T	DO43041	UCEC	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1389
p.L172M	TCGA-CK-6746	COAD	TCGA	AHTST	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1944
p.L172M	DO7938	COAD	ICGC	AHTST	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1944
p.S453L	TCGA-CM-5861	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.6556
p.S453L	DO7918	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.6556
p.S453L	ACH-001864	Bile Duct Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.6556
p.S617N	TCGA-D1-A103	UCEC	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1667
p.S617N	TCGA-D1-A103	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2778
p.S617N	DO42312	UCEC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1667
p.S617N	DO42312	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2778
p.P608S	TCGA-D3-A8GI	SKCM	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.5641
p.P608S	TCGA-W3-A824	SKCM	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.5641
p.P608S	DO50284	SKCM	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.5641
p.P608S	DO51271	SKCM	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.5641
p.P608S	SIDM01175	Other Sarcomas	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.5641
p.P608S	ACH-002309	Sarcoma	CCLE	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.5641
p.P608S	SW684	soft tissue	COSMIC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.5641
p.L444F	TCGA-D3-A8GL	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1111
p.L444F	DO50287	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1111
p.T495S	TCGA-DD-A3A3	LIHC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.3056
p.T495S	DO44878	LIHC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.3056
p.P599R	TCGA-DJ-A3VI	THCA	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.2222
p.P599R	DO223938	THCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.2222
p.T596I	TCGA-EE-A29B	SKCM	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1389
p.T596I	DO47255	SKCM	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1389
p.V496F	TCGA-EO-A22X	UCEC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.7068
p.V496F	DO43907	UCEC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.7068
p.R508I	TCGA-HE-7128	KIRP	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.1667
p.R508I	DO20796	KIRP	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.1667
p.P459L	TCGA-HF-7132	STAD	TCGA	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.25
p.P459L	DO38214	STAD	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.25
p.P499S	TCGA-HU-A4H8	STAD	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6752
p.P499S	DO47869	STAD	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation altering degron motif	0.6752
p.V510L	TCGA-L5-A4OS	ESCA	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.1111
p.A512T	TCGA-NC-A5HT	LUSC	TCGA	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0556
p.A512T	DO219205	LUSC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0556
p.T506I	DO48393	BLCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.T506I	DO222884	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.T506I	DO229013	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.T506I	DO229016	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.T506I	DO229003	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.T506I	DO229005	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.T506I	DO52365	LUSC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.2222
p.A505T	DO48379	BLCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A505T	DO229013	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A505T	DO229016	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A505T	DO229003	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A505T	DO229005	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A505T	DO51032	LAML	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A505T	DO23549	LIRI	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A505T	DO52365	LUSC	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A595T	DO48422	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO229013	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO229016	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO229003	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO229005	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO230659	LAML	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO231140	LAML	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO52365	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO231022	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO231189	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO229456	SKCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.A595T	DO229515	SKCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.D605A	DO48410	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO228483	BRCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO224731	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO222782	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO222866	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO229010	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO229005	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO225404	LAML	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO52365	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO52357	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO52359	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.D605A	DO218843	SKCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6682
p.P394A	DO44097	BLCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.7503
p.G391S	DO225139	BRCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G391S	DO224645	COCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G391S	DO222826	COCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G391S	DO229354	LAML	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G391S	DO51022	LAML	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G391S	DO51004	LAML	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G391S	DO224551	LUSC	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G391S	DO228665	PRAD	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G391S	DO228725	PRAD	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.G620V	DO222955	BTCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0833
p.G620V	DO222955	BTCA	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.1944
p.S399P	DO52713	CLLE	ICGC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5641
p.T442I	DO230334	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.T442I	DO229010	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.T442I	DO229013	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.T442I	DO229003	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.T442I	DO229005	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.T442I	DO229346	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.T442I	DO50981	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.T442I	DO51011	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.T442I	DO229470	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.D493H	DO229010	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.D493H	DO229013	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.D493H	DO229016	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.D493H	DO229003	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.D493H	DO229005	COCA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.P611S	DO234177	ESAD	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.5641
p.P611S	DO234177	ESAD	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.6752
p.P612L	DO233726	GACA	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.6471
p.P612L	DO228176	PBCA	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.6471
p.S66P	DO229505	LAML	ICGC	AETSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.6752
p.T447M	DO231159	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1944
p.R619L	DO45127	LIRI	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1111
p.R619L	DO45127	LIRI	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2222
p.L444P	DO231075	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1111
p.G598V	DO231049	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1944
p.S609F	DO222567	MELA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation altering degron motif	0.6871
p.T486I	DO222875	MELA	ICGC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0556
p.G620R	DO232812	PBCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0833
p.G620R	DO232812	PBCA	ICGC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.1944
p.E466D	DO232532	PBCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.E466D	DO218861	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.A452T	DO219878	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7139
p.I75V	DO227681	SKCA	ICGC	AETSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0833
p.I594M	SIDM00656	Burkitt's Lymphoma	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0833
p.I594M	SIDM00641	Burkitt's Lymphoma	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0833
p.I594M	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0833
p.W400C	SIDM00318	Kidney Carcinoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5889
p.W400C	SIDM01139	Pancreatic Carcinoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5889
p.W400C	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5889
p.W400C	SIDM01066	Melanoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5889
p.W400C	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5889
p.V510M	SIDM00315	Glioblastoma	GDSC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.1111
p.V510M	ACH-000570	Brain Cancer	CCLE	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.1111
p.L461Q	SIDM00457	Plasma Cell Myeloma	GDSC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1944
p.L461Q	OPM-2	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1944
p.D457N	SIDM00847	Rhabdomyosarcoma	GDSC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.3056
p.D457N	ACH-000169	Sarcoma	CCLE	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.3056
p.D457N	RD	soft tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.3056
p.I594V	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.0833
p.T624A	SIDM00534	Colorectal Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.0833
p.T624A	ACH-000986	Colon/Colorectal Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.0833
p.T624A	HT-115	large intestine	COSMIC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.0833
p.D443N	SIDM00975	Melanoma	GDSC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0833
p.D443N	ACH-002206	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0833
p.D443N	WM278	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0833
p.T156K	SIDM01470	Acute Myeloid Leukemia	GDSC	AHTST	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1389
p.A490V	SIDM00500	Colorectal Carcinoma	GDSC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.1667
p.A490V	ACH-000959	Colon/Colorectal Cancer	CCLE	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.1667
p.P402L	HCC1569	breast	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.P402L	EB2	haematopoietic and lymphoid tissue	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.P402L	EB-3	haematopoietic and lymphoid tissue	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.P402L	MDA-MB-157	breast	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.P402L	NCI-H835	lung	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.P402L	NCI-H748	lung	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.P402L	NB13	autonomic ganglia	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.P402L	RKO	large intestine	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.P402L	NCI-H2110	lung	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.R495P	AMO-1	haematopoietic and lymphoid tissue	COSMIC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.3056
p.R495P	KYSE-270	oesophagus	COSMIC	VGTPLPT	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.3056
p.L409F	HN	upper aerodigestive tract	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1111
p.S399F	Hep_3B2_1-7	NS	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.6871
p.R448Q	BT-474	breast	COSMIC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.D408N	WM278	skin	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1389
p.T453A	HT-115	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7139
p.T392I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2778
p.V406A	KYSE-150	oesophagus	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1944
p.P466S	TMK-1	stomach	COSMIC	ASSTS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.A396S	Becker	central nervous system	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.7588
p.T617A	NB7	autonomic ganglia	COSMIC	SRDPLPSVP	DEG_APCC_DBOX_1	603:611	Mutation rewiring degron network	0.1667
p.T617A	NB7	autonomic ganglia	COSMIC	PPTTT	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.2778
p.A408T	SCC-4	upper aerodigestive tract	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1389
p.S390N	RPMI-6666	haematopoietic and lymphoid tissue	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MUC20

UniProt ID: Q8N307

Entrez ID: 200958

Protein name: Mucin-20 (MUC-20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MUC20 in