DegronMD

Uniprot ID: Q8N307

Source protein: Mucin-20

Source gene: MUC20

Class: DEG_SPOP_SBC_1

Location: 163:167

E3 ligase: SPOP

DEGRON score: 0.9811

ASA_SCORE: 82.34

COIL: 0.8552

CONS_SCORE: 0.7914

DSS_SCORE: 0.4411

HELIX: 0.0508

FCONS_SCORE: 1.5544

RIG_SCORE: 0.7629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T161I	TCGA-43-8116	LUSC	TCGA	AHTST	DEG_SPOP_SBC_1	0.7222
p.T161I	DO27349	LUSC	ICGC	AHTST	DEG_SPOP_SBC_1	0.7222
p.L172M	TCGA-CK-6746	COAD	TCGA	AHTST	DEG_SPOP_SBC_1	0.1944
p.L172M	DO7938	COAD	ICGC	AHTST	DEG_SPOP_SBC_1	0.1944
p.T156K	SIDM01470	Acute Myeloid Leukemia	GDSC	AHTST	DEG_SPOP_SBC_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons