DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 2017:2021

E3 ligase: SPOP

DEGRON score: 0.6268

ASA_SCORE: 89.54

COIL: 0.8692

CONS_SCORE: 0.2195

DSS_SCORE: 0.6342

HELIX: 0.0342

FCONS_SCORE: 1.034

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2024N	TCGA-90-7769	LUSC	TCGA	AHTST	DEG_SPOP_SBC_1	0.25
p.G2031V	TCGA-CD-A4MG	STAD	TCGA	AHTST	DEG_SPOP_SBC_1	0.0556
p.T2028S	TCGA-CJ-4902	KIRC	TCGA	AHTST	DEG_SPOP_SBC_1	0.1389
p.G2031E	TCGA-EE-A29M	SKCM	TCGA	AHTST	DEG_SPOP_SBC_1	0.0556
p.T2031S	DO17693	KIRC	ICGC	AHTST	DEG_SPOP_SBC_1	0.0556
p.A2030S	DO229019	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	0.0833
p.A2011S	DO229025	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	0.1667
p.T2027N	DO26822	LUSC	ICGC	AHTST	DEG_SPOP_SBC_1	0.1667
p.A2017V	H290	pleura	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	NCI-H2444	lung	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	TOV-21G	ovary	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	HPAC	pancreas	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	KARPAS-299	haematopoietic_and_lymphoid_tissue	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	RPMI-2650	upper_aerodigestive_tract	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	U-118-MG	central_nervous_system	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	GCT	soft_tissue	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	HCC202	breast	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	CHSA0108	bone	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	BICR78	upper_aerodigestive_tract	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	D-423MG	central_nervous_system	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	M059J	central_nervous_system	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825
p.A2017V	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	AHTST	DEG_SPOP_SBC_1	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons