DegronMD - Q9H5V7(IKZF5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D210Y	TCGA-04-1651	OV	TCGA	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0556
p.D210Y	DO27983	OV	ICGC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0556
p.S192R	TCGA-05-4250	LUAD	TCGA	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.6316
p.S192R	DO229029	LICA	ICGC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.6316
p.S192R	DO24457	LUAD	ICGC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.6316
p.R193T	TCGA-44-5644	LUAD	TCGA	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7876
p.R193T	DO25153	LUAD	ICGC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7876
p.V327A	TCGA-AN-A046	BRCA	TCGA	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0833
p.V327A	DO1285	BRCA	ICGC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0833
p.V300I	TCGA-BG-A0LX	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1944
p.V300I	DO41919	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1944
p.P201L	TCGA-D3-A2JL	SKCM	TCGA	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.P201L	DO47278	SKCM	ICGC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.P334A	TCGA-D8-A1XK	BRCA	TCGA	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2778
p.P334A	DO4749	BRCA	ICGC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2778
p.L199V	DO223020	ESCA	ICGC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.5654
p.P330T	DO228952	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1667
p.P348Q	DO228974	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.P326Q	DO229019	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556
p.P209T	DO229022	LICA	ICGC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0833
p.S342R	DO229036	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2778
p.T338K	DO229037	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.7306
p.S346G	DO229211	THCA	ICGC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1667
p.S187N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1944
p.S187N	ACH-002256	Leukemia	CCLE	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1944
p.S187N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1944
p.P202H	SIDM00820	Kidney Carcinoma	GDSC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2778
p.P202H	ACH-002188	Kidney Cancer	CCLE	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2778
p.P202H	RCC-ER	kidney	COSMIC	SRRALINLS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2778
p.P348S	SIDM00217	Colorectal Carcinoma	GDSC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.P348S	SIDM00980	Gastric Carcinoma	GDSC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.P348S	ACH-000948	Gastric Cancer	CCLE	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.P348S	ACH-000999	Colon/Colorectal Cancer	CCLE	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.P348S	23132-87	stomach	COSMIC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.P348S	SNU-1040	large intestine	COSMIC	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.S349G	ACH-001664	Gastric Cancer	CCLE	AHTST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0833

Kaplan plot for IKZF5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IKZF5

UniProt ID: Q9H5V7

Entrez ID: 64376

Protein name: Zinc finger protein Pegasus (Ikaros family zinc finger protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IKZF5 in